Plasma levels of matrix metalloproteinase-9: a possible diagnostic marker of successful endovascular aneurysm repair.

Abstract

OBJECTIVE:

The aim of the study was evaluating the diagnostic value of plasma matrix metalloproteinase- (MMP)-2 and -9 and tissue inhibitor of MMP-1 (TIMP-1) for endoleak detection after endovascular aneurysm repair (EVAR).

REPORT:

Consecutive EVAR patients (n = 17) with endoleak and matched controls without endoleak (n = 20) were prospectively enrolled. Increased levels of MMP-9 were observed in patients with endoleak (P < 0.001). Regression analysis showed no significant influence of age, sex or abdominal aortic aneurysm (AAA) size. The receiver operating characteristic (ROC) curve of plasma MMP-9 levels showed that a cut-off value of 55.18 ng ml(-1) resulted in 100% sensitivity and 96% specificity with an AUC value of 0.988 (P < 0.001) to detect endoleak.

CONCLUSIONS:

Plasma MMP-9 levels appear to discriminate between patients with and without an endoleak with high sensitivity and specificity.

• Authors: F A M V I Hellenthal, J A Ten Bosch, B Pulinx, W K W H Wodzig, M W de Haan, M H Prins, R J T J Welten, J A W Teijink, G W H Schurink
• Journal: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery (Eur J Vasc Endovasc Surg) Vol. 43 Issue 2 Pg. 171-2 (Feb 2012) ISSN: 1532-2165 [Electronic] England
• PMID: 22172237 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Biomarkers
• Protease Inhibitors
• TIMP1 protein, human
• Tissue Inhibitor of Metalloproteinase-1
• MMP2 protein, human
• Matrix Metalloproteinase 2
• Matrix Metalloproteinase 9

Topics

• Aged
• Aged, 80 and over
• Angiography
• Aortic Aneurysm, Abdominal (blood, surgery)
• Biomarkers (blood)
• Blood Vessel Prosthesis Implantation
• Case-Control Studies
• Endoleak (blood, diagnostic imaging)
• Enzyme-Linked Immunosorbent Assay
• Female
• Follow-Up Studies
• Humans
• Male
• Matrix Metalloproteinase 2 (blood)
• Matrix Metalloproteinase 9 (blood)
• Middle Aged
• Prospective Studies
• Protease Inhibitors (blood)
• ROC Curve
• Regression Analysis
• Sensitivity and Specificity
• Tissue Inhibitor of Metalloproteinase-1 (blood)
• Tomography, X-Ray Computed