HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Case in which tranilast ophthalmic solution was thought to be effective for the prevention of symblepharon and recurrence after pterygium surgery.

Abstract
We report our experience of a case in which a combination of conjunctival symblepharon detachment, conjunctival granuloma excision, and conjunctival free flap transplantation was performed for the treatment of symblepharon after pterygium surgery, with satisfactory outcomes. The patient was referred to our hospital with pterygium recurrence, symblepharon and granuloma formation after pterygium surgery in the right eye at another hospital. We performed conjunctival symblepharon detachment along with conjunctival autograft transplantation, and started instillation of tranilast ophthalmic solution immediately after the surgery, to inhibit proliferation and adhesion formation. During the 6 months' follow-up of the patient at our hospital, the postoperative course was satisfactory, and no recurrence of symblepharon, pterygium or granuloma was observed. There were no adverse drug reactions associated with the instillation of tranilast ophthalmic solution. Tranilast ophthalmic solution may be effective not only for prevention of pterygium recurrence, but also for inhibition of symblepharon and granuloma formation.
AuthorsAkira Tsuji, Kenji Kawai, Haiyan Fan, Yoshihiro Nakagawa, Takahiro Suzuki
JournalThe Tokai journal of experimental and clinical medicine (Tokai J Exp Clin Med) Vol. 36 Issue 4 Pg. 120-3 (Dec 20 2011) ISSN: 2185-2243 [Electronic] Japan
PMID22167494 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Ophthalmic Solutions
  • ortho-Aminobenzoates
  • tranilast
Topics
  • Conjunctiva (transplantation)
  • Conjunctival Diseases (prevention & control, surgery)
  • Granuloma (prevention & control, surgery)
  • Humans
  • Instillation, Drug
  • Male
  • Middle Aged
  • Ophthalmic Solutions
  • Pterygium (prevention & control, surgery)
  • Secondary Prevention
  • Treatment Outcome
  • ortho-Aminobenzoates (administration & dosage)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: