Urinary prostaglandin E2 metabolite and risk for colorectal adenoma.

Abstract

COX-2 is upregulated in most colorectal cancers. Most of the COX-2 tumor-inducing effects are believed to be mediated through overproduction of prostaglandin E(2) (PGE(2)), which can be measured using a urinary metabolite of PGE(2), PGE-M. Urinary PGE-M was assessed in a case-control study of colorectal adenoma. Included in the analysis were 224 cases with at least one advanced adenoma, 152 cases with multiple small tubular adenomas, 300 cases with only a single small tubular adenoma, and 364 polyp-free controls. There were no statistical differences in PGE-M levels between controls and cases with a single small tubular adenoma. However, cases with either an advanced adenoma or multiple small tubular adenomas had more than 25% higher levels of PGE-M than controls. Participants with the highest quartile level of PGE-M were approximately 2.5-fold more likely to have advanced or multiple small tubular adenoma in comparison with those with the lowest level of PGE-M [OR = 2.53; 95% confidence interval (CI), 1.54-4.14; P(trend) < 0.001]. The association was strongest among women. PGE-M level was associated with increased risk for multiple or advanced adenoma but not single small adenoma. Our study suggests that PGE-M may be a useful risk marker for assessing the risk of harboring clinically more important versus less important colorectal neoplasia.

• Authors: Martha J Shrubsole, Qiuyin Cai, Wanqing Wen, Ginger Milne, Walter E Smalley, Zhi Chen, Reid M Ness, Wei Zheng
• Journal: Cancer prevention research (Philadelphia, Pa.) (Cancer Prev Res (Phila)) Vol. 5 Issue 2 Pg. 336-42 (Feb 2012) ISSN: 1940-6215 [Electronic] United States
• PMID: 22166248 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: ©2011 AACR.

Chemical References

• Biomarkers, Tumor
• Prostaglandins
• 7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid
• Cyclooxygenase 2
• PTGS2 protein, human
• Dinoprostone

Topics

• Adenoma (etiology, urine)
• Adult
• Aged
• Biomarkers, Tumor (urine)
• Case-Control Studies
• Colorectal Neoplasms (etiology, urine)
• Cyclooxygenase 2 (metabolism)
• Dinoprostone (metabolism)
• Female
• Humans
• Male
• Middle Aged
• Prognosis
• Prostaglandins (urine)