Occupational risk factors and pancreatic cancer: a review of recent findings.

Abstract

Several occupational exposures have been linked to excess risk of pancreatic cancer; however, most associations are not well established. The objective of this review article is to report on the more recently published studies (1998-2010), and provide a summary of the most consistently reported occupational risk factors for pancreatic cancer, including exposure to chlorinated hydrocarbon compounds, pesticides, polycyclic aromatic hydrocarbons (PAHs), metals, nitrosamines, radiation, various airborne particles, and employment in sedentary occupations. We conclude that the strongest and most consistent findings linking occupational exposures with pancreatic cancer risk to date are for chlorinated hydrocarbons and PAHs.

• Authors: Gabriella Andreotti, Debra T Silverman
• Journal: Molecular carcinogenesis (Mol Carcinog) Vol. 51 Issue 1 Pg. 98-108 (Jan 2012) ISSN: 1098-2744 [Electronic] United States
• PMID: 22162234 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2011 Wiley Periodicals, Inc.

Chemical References

• Hydrocarbons, Chlorinated
• Nitrosamines
• Particulate Matter
• Pesticides
• Polycyclic Aromatic Hydrocarbons

Topics

• Humans
• Hydrocarbons, Chlorinated (toxicity)
• Nitrosamines (toxicity)
• Occupational Exposure
• Pancreatic Neoplasms (chemically induced, epidemiology, etiology)
• Particulate Matter (toxicity)
• Pesticides (toxicity)
• Polycyclic Aromatic Hydrocarbons (toxicity)
• Risk Factors
• Sedentary Behavior