Flavanones inhibit the clonogenicity of HCT116 cololectal cancer cells.

Abstract

Naringenin has been shown to display various biological effects such as antioxidant, anticancer, anti-inflammatory, and antiviral activities. Taxifolin inhibits the production of lipopolysaccharide-induced prostaglandin E, and fustin suppresses the activity of acetylcholinesterase. They all belong to flavanone which is a class of flavonoids with a C6-C3-C6 skeleton. Since the anticancer activities of flavanone derivatives have rarely been reported, we examined the effects of 26 flavanone derivatives on HCT116 colorectal cancer cells. Our results suggest that flavanone derivatives control the expression of cell cycle regulatory proteins, which blocks G1 cell cycle progression and inhibits the clonogenicity of HCT116 cells. In addition, in order to design flavanone derivatives that show better anticancer activity, structure-activity relationships were examined.

• Authors: Yoonkyung Woo, Soon Young Shin, Jiye Hyun, Sung Dae Lee, Young Han Lee, Yoongho Lim
• Journal: International journal of molecular medicine (Int J Mol Med) Vol. 29 Issue 3 Pg. 403-8 (Mar 2012) ISSN: 1791-244X [Electronic] Greece
• PMID: 22160193 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Flavanones

Topics

• Antineoplastic Agents (chemistry, pharmacology)
• Carbohydrate Conformation
• Colorectal Neoplasms (metabolism)
• Flavanones (chemistry, pharmacology)
• HCT116 Cells
• Humans
• Models, Molecular
• Quantitative Structure-Activity Relationship
• Tumor Stem Cell Assay