Abstract |
A series of ruthenium complexes containing bis-benzimidazole derivatives have been synthesized and identified as able to target mitochondria and induce caspase-dependent apoptosis in cancer cells through superoxide overproduction.
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Authors | Linlin Li, Yum-Shing Wong, Tianfeng Chen, Cundong Fan, Wenjie Zheng |
Journal | Dalton transactions (Cambridge, England : 2003)
(Dalton Trans)
Vol. 41
Issue 4
Pg. 1138-41
(Jan 28 2012)
ISSN: 1477-9234 [Electronic] England |
PMID | 22159211
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Benzimidazoles
- Organometallic Compounds
- Ruthenium
- benzimidazole
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Topics |
- Antineoplastic Agents
(chemistry, pharmacology)
- Apoptosis
(drug effects)
- Benzimidazoles
(chemistry)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Humans
- Inhibitory Concentration 50
- Organometallic Compounds
(chemistry, pharmacology)
- Ruthenium
(chemistry)
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