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Ruthenium complexes containing bis-benzimidazole derivatives as a new class of apoptosis inducers.

Abstract
A series of ruthenium complexes containing bis-benzimidazole derivatives have been synthesized and identified as able to target mitochondria and induce caspase-dependent apoptosis in cancer cells through superoxide overproduction.
AuthorsLinlin Li, Yum-Shing Wong, Tianfeng Chen, Cundong Fan, Wenjie Zheng
JournalDalton transactions (Cambridge, England : 2003) (Dalton Trans) Vol. 41 Issue 4 Pg. 1138-41 (Jan 28 2012) ISSN: 1477-9234 [Electronic] England
PMID22159211 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Benzimidazoles
  • Organometallic Compounds
  • Ruthenium
  • benzimidazole
Topics
  • Antineoplastic Agents (chemistry, pharmacology)
  • Apoptosis (drug effects)
  • Benzimidazoles (chemistry)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Humans
  • Inhibitory Concentration 50
  • Organometallic Compounds (chemistry, pharmacology)
  • Ruthenium (chemistry)

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