Abstract | PURPOSE OF REVIEW: This review summarizes the results of recent studies regarding the biology and pharmacology of novel synthetic agonists and antagonists of the bombesin receptor subtype-3 (BRS-3). RECENT FINDINGS: SUMMARY: The native ligand of the G protein-coupled BRS-3 has not been identified as of now. However, novel synthesis of small-molecule, high-affinity agonists and antagonists on the BRS-3 was used in the recent studies and demonstrated an important role of BRS-3 in the regulation of energy homeostasis and glucose metabolism.
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Authors | Ishita D Majumdar, Horst C Weber |
Journal | Current opinion in endocrinology, diabetes, and obesity
(Curr Opin Endocrinol Diabetes Obes)
Vol. 19
Issue 1
Pg. 3-7
(Feb 2012)
ISSN: 1752-2978 [Electronic] England |
PMID | 22157398
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Chemical References |
- Appetite Depressants
- Blood Glucose
- Receptors, Bombesin
- bombesin receptor subtype 3
- Gastrin-Releasing Peptide
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Topics |
- Animals
- Appetite Depressants
(pharmacology)
- Appetite Regulation
(drug effects)
- Blood Glucose
- Diabetes Mellitus, Type 2
(drug therapy, metabolism)
- Energy Metabolism
- Gastrin-Releasing Peptide
(pharmacology)
- Homeostasis
- Humans
- Mice
- Mice, Knockout
- Obesity
(drug therapy, metabolism)
- Receptors, Bombesin
(agonists, antagonists & inhibitors, metabolism)
- Satiety Response
(drug effects)
- Signal Transduction
(drug effects)
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