Abstract | OBJECTIVE: To study the organisms causing early and late onset neonatal sepsis, with special reference to multi-drug resistant gram negative bacilli, at two neonatal units (one urban, one rural) in India. METHODS: Prospective surveillance study. RESULTS: There were 159 episodes of sepsis (81 urban and 77 rural) affecting 158 babies. Gram negative bacilli caused 117 infections (68%) and predominated at both centres in both early and late sepsis. Klebsiella pneumoniae was the commonest organism, causing 61 infections (38.3%). In early sepsis (0-2 days), non-fermenting gram negative bacilli caused 42.1% of infections at the urban centre; there were no cases of early Group B Streptococcus sepsis. Late onset sepsis was mainly caused by gram negative bacilli at both centres. Multi-drug resistance of over 80% of early-onset gram negative organisms to ampicillin, third generation cephalosporins and gentamicin indicates that these multi-resistant organisms are almost certainly circulating widely in the community. The overall mortality from early sepsis was 27.3% (9 of 33) and from late sepsis was 26.2% (33 of 126). Gram negative bacilli caused all deaths from early sepsis and 87.5% of deaths from late sepsis. CONCLUSION: This study shows that multi-drug resistant gram negative bacilli are a major cause of early and late neonatal sepsis in India and are almost certainly widespread in the community.
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Authors | Rajlakshmi Viswanathan, Arun Kumarendu Singh, Sulagna Basu, Suparna Chatterjee, Syamal Sardar, David Isaacs |
Journal | Archives of disease in childhood. Fetal and neonatal edition
(Arch Dis Child Fetal Neonatal Ed)
Vol. 97
Issue 3
Pg. F182-7
(May 2012)
ISSN: 1468-2052 [Electronic] England |
PMID | 22155619
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Age Factors
- Anti-Bacterial Agents
(therapeutic use)
- Birth Weight
- Drug Resistance, Multiple, Bacterial
- Gestational Age
- Gram-Negative Bacteria
(drug effects)
- Gram-Negative Bacterial Infections
(drug therapy, epidemiology, microbiology)
- Humans
- Incidence
- India
(epidemiology)
- Infant, Newborn
- Intensive Care Units, Neonatal
- Prospective Studies
- Rural Health
(statistics & numerical data)
- Sepsis
(epidemiology, microbiology)
- Urban Health
(statistics & numerical data)
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