[Fulminant autoimmune cold-type hemolysis with marked elevation of monothermic cold agglutinins. Successful therapy with membrane plasmapheresis].

Abstract

Autoimmune hemolytic anemia associated with cold autoantibodies is rare in infancy. In a 7 months old infant with severe hemolysis, a hemoglobin of 5.9 g/dl and a cold agglutinin titer of 1:8000, even the transfusion of warmed, packed red cells (37 degrees C) lead to hemolysis. Hemoglobin fell to 2.8 g/dl despite prevention of exposure to cold, parenteral steroids and immunoglobulins. Cold agglutinin titer fell to 1:8 after plasma separation. Subsequent transfusion did not lead to hemolysis and permanent remission was achieved.

• Authors: N Gordjani, V Kretschmer, U Töllner, C Rieger
• Journal: Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde (Monatsschr Kinderheilkd) Vol. 138 Issue 8 Pg. 454-6 (Aug 1990) ISSN: 0026-9298 [Print] Germany
• Vernacular Title: Foudroyant verlaufende Autoimmunhämolyse vom Kältetyp mit ausgeprägter Vermehrung von monothermischen Kälteagglutininen: Erfolgreiche Therapie mit Membranplasmapherese.
• PMID: 2215510 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Agglutinins
• Cryoglobulins
• cold agglutinins

Topics

• Agglutinins (analysis)
• Anemia, Hemolytic, Autoimmune (blood, therapy)
• Cryoglobulins
• Female
• Humans
• Infant
• Plasmapheresis