Abstract | OBJECTIVE: METHODS: A total of 40 male Sprague-Dawley rats were randomized into normal control group, model group, methotrexate (MTX) group, Tripterygium Wilfordii polycoride Tablet ( TPT) group, and XFC group, respectively. AA was induced in rats by intracutaneous injection of 0.1 mL Freund's complete adjuvant in the right hindlimb. Contents of PAF, IL-6 and IL-17 in peripheral blood were measured by enzyme-linked immunosorbent assay. Body weight of rats, paw swelling and arthritis index (AI) were also observed. RESULTS: Compared with the normal control group, the levels of PAF, IL-6 and IL-17 in peripheral blood, paw swelling and AI were significantly increased in the model group (P<0.01). Compared with the model group, levels of PAF, IL-6 and IL-17, paw swelling and AI of the three drug-treated groups were significantly decreased (P<0.01). The body weight of the XFC group was significantly higher than those of the MTX- and TPT-treated groups. Compared with the MTX- and TPT-treated groups, level of PAF in the XFC group was significantly increased (P<0.05). The level of PAF in peripheral blood of the AA rats was positively correlated with IL-6 and IL-17 levels in peripheral blood, paw swelling and AI (P<0.01). CONCLUSION: The expression of PAF increases in peripheral blood of rats with AA, and it correlates with IL-6, IL-17, paw swelling and AI. XFC can decrease the expression of PAF, restrain infection induced by the activation of platelets, decrease the levels of IL-6 and IL-17, and hence decrease the paw swelling of rats with AA.
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Authors | Rui-kai Zong, Jian Liu |
Journal | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
(Zhong Xi Yi Jie He Xue Bao)
Vol. 9
Issue 12
Pg. 1347-52
(Dec 2011)
ISSN: 1672-1977 [Print] China |
PMID | 22152774
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drugs, Chinese Herbal
- Interleukin-17
- Interleukin-6
- Platelet Activating Factor
- xinfeng
- Methotrexate
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Topics |
- Animals
- Arthritis, Experimental
(blood, drug therapy)
- Drugs, Chinese Herbal
(therapeutic use)
- Interleukin-17
(blood)
- Interleukin-6
(blood)
- Male
- Methotrexate
(therapeutic use)
- Phytotherapy
- Platelet Activating Factor
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Tripterygium
(chemistry)
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