Abstract |
The potency of the oxime HI-6 and two combinations of oximes ( HI-6 + trimedoxime, HI-6 + K203) to reduce sarin-induced acute neurotoxic signs and symptoms was evaluated in this study. Sarin-induced neurotoxicity and the neuroprotective effects of atropine alone or in combination with HI-6 alone and HI-6 combined with trimedoxime or K203 in rats poisoned with sarin at a sublethal dose (108 μg/kg i.m.; 90% of LD(50) value) were monitored by a functional observatory battery (FOB) 24 h following sarin administration. The results indicate that both mixtures of oximes combined with atropine were able to survive sarin-poisoned rats 24 h following sarin administration while two non-treated sarin-poisoned rats and one sarin-poisoned rat treated with atropine alone or with atropine in combination with the oxime HI-6 died within 24 h following sarin poisoning. All types of antidotal treatment were able to decrease sarin-induced neurotoxic signs and symptoms but not completely. While atropine alone and atropine in combination with the oxime HI-6 were able to eliminate some sarin-induced neurotoxic signs and symptoms, the neuroprotective efficacy of both combinations of oximes with atropine was slightly higher. Thus, both tested combinations of oximes in combination with atropine bring a small benefit for the neuroprotective efficacy of antidotal treatment of acute sarin poisonings.
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Authors | Jiri Kassa, Gabriela Kunesova |
Journal | Toxicology mechanisms and methods
(Toxicol Mech Methods)
Vol. 22
Issue 4
Pg. 260-7
(May 2012)
ISSN: 1537-6524 [Electronic] England |
PMID | 22149934
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene
- Antidotes
- Chemical Warfare Agents
- Cholinesterase Inhibitors
- Cholinesterase Reactivators
- Neuroprotective Agents
- Oximes
- Pyridinium Compounds
- Trimedoxime
- Atropine
- Sarin
- asoxime chloride
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Topics |
- Animals
- Antidotes
(administration & dosage, therapeutic use)
- Atropine
(chemistry)
- Chemical Warfare Agents
(poisoning, toxicity)
- Cholinesterase Inhibitors
(poisoning, toxicity)
- Cholinesterase Reactivators
(administration & dosage, therapeutic use)
- Drug Therapy, Combination
- Male
- Molecular Structure
- Neuroprotective Agents
(therapeutic use)
- Oximes
(administration & dosage, chemistry, therapeutic use)
- Pyridinium Compounds
(administration & dosage, chemistry, therapeutic use)
- Rats
- Rats, Wistar
- Sarin
(poisoning, toxicity)
- Trimedoxime
(administration & dosage, chemistry, therapeutic use)
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