HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication.

Abstract
The level of cholesterol in host cells has been shown to affect viral infection. However, it is still not understood why this level of regulation is important for successful infection. We have shown in this study that dengue virus infection was affected when the cholesterol intake in infected cells was disrupted using a cholesterol transport inhibitor, U18666A. The antiviral effect was found to result from two events: retarded viral trafficking in the cholesterol-loaded late endosomes/lysosomes and suppressed de novo sterol biosynthesis in treated infected cells. We also observed an additive antiviral effect of U18666A with C75, a fatty acid synthase inhibitor, suggesting dengue virus relies on both the host cholesterol and fatty acid biosynthesis for successful replication.
AuthorsMee Kian Poh, Guanghou Shui, Xuping Xie, Pei-Yong Shi, Markus R Wenk, Feng Gu
JournalAntiviral research (Antiviral Res) Vol. 93 Issue 1 Pg. 191-8 (Jan 2012) ISSN: 1872-9096 [Electronic] Netherlands
PMID22146564 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier B.V. All rights reserved.
Chemical References
  • 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid
  • Androstenes
  • Anticholesteremic Agents
  • Antiviral Agents
  • 3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one
  • Cholesterol
  • Fatty Acid Synthases
  • 4-Butyrolactone
Topics
  • 4-Butyrolactone (analogs & derivatives, pharmacology)
  • Androstenes (pharmacology)
  • Animals
  • Anticholesteremic Agents (pharmacology)
  • Antiviral Agents (pharmacology)
  • Biological Transport (drug effects)
  • Cell Line
  • Cholesterol (metabolism)
  • Cricetinae
  • Dengue Virus (drug effects)
  • Drug Synergism
  • Endosomes (drug effects, metabolism)
  • Fatty Acid Synthases (antagonists & inhibitors)
  • Humans
  • Lysosomes (drug effects, metabolism)
  • Virus Internalization (drug effects)
  • Virus Replication (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: