Abstract | BACKGROUND: PROCEDURE: Between November 2009 and January 2011, 12 consecutive patients with WT were included in the study. Preoperative chemotherapy consisted of vincristine (1.4 mg/m, days 1, 8, 15, and 22) and doxorubicin (20 mg/m, 1 to 3 d). RESULTS: All renal tumors showed shrinkage drastically after 4 weeks of preoperative chemotherapy. Surgery of all the patients was uneventful and without any complications. At the end of the median follow-up time of 8 months (range, 6 to 17 mo), all patients are in remission without a sign of the disease. CONCLUSIONS: Preoperative chemotherapy consisting of vincristine and doxorubicin seems to be successful as a preoperative treatment in achieving shrinkage and reducing the risk of surgical complications. On the basis of the promising results in our study, it is worth administering a similar regimen with further follow-up in larger populations.
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Authors | Serhan Küpeli, Salim Bilici |
Journal | Journal of pediatric hematology/oncology
(J Pediatr Hematol Oncol)
Vol. 34
Issue 3
Pg. e106-9
(Apr 2012)
ISSN: 1536-3678 [Electronic] United States |
PMID | 22146531
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Chemotherapy, Adjuvant
- Child
- Child, Preschool
- Doxorubicin
(administration & dosage)
- Female
- Follow-Up Studies
- Humans
- Kidney Neoplasms
(drug therapy, pathology)
- Male
- Middle Aged
- Prognosis
- Prospective Studies
- Survival Rate
- Vincristine
(administration & dosage)
- Wilms Tumor
(drug therapy, pathology)
- Young Adult
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