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Lurasidone: a new treatment option for schizophrenia.

Abstract
Lurasidone is a novel benzoisothiazol antipsychotic that has recently been approved for the treatment of schizophrenia in the U.S. Like many other second-generation antipsychotics, it has a high affinity for dopamine D(2) and serotonin 5-HT(2A) receptors as well as a high affinity for 5-HT(7) receptors. It has negligible affinity for α(1)-adrenoceptors, histamine H(1) receptors or muscarinic acetylcholine M(1) receptors. It has demonstrated efficacy in short-term trials versus placebo, two of which included an active comparator (olanzapine, quetiapine) assay arm. A short-term, head-to-head trial of lurasidone versus ziprasidone in chronic stable schizophrenia was also conducted. A long-term, 12-month risperidone-controlled study and open-label studies primarily investigated the safety and tolerability of lurasidone. Limited evidence of procognitive and antidepressant effects was seen although these need further corroboration. The incidence of extrapyramidal symptoms (excluding akathisia/restlessness) was greater with lurasidone (14.7%) than placebo (5.1%). Akathisia and somnolence were dose-related adverse events. Lurasidone appears to have relatively little effect on weight, plasma glucose or lipids to date. No evidence of QTc prolongation was seen and orthostatic hypotension was uncommon. Raised prolactin levels in short-term studies were dose-dependent, greater in females and occurred overall in 3.7 and 0.7% of lurasidone and placebo recipients, respectively.
AuthorsR T Owen
JournalDrugs of today (Barcelona, Spain : 1998) (Drugs Today (Barc)) Vol. 47 Issue 11 Pg. 807-16 (Nov 2011) ISSN: 1699-3993 [Print] Spain
PMID22146224 (Publication Type: Journal Article, Review)
CopyrightCopyright 2011 Prous Science, S.A.U. or its licensors. All rights reserved.
Chemical References
  • Antipsychotic Agents
  • Isoindoles
  • Thiazoles
  • Lurasidone Hydrochloride
Topics
  • Antipsychotic Agents (adverse effects, pharmacokinetics, pharmacology, therapeutic use)
  • Clinical Trials as Topic
  • Drug Interactions
  • Humans
  • Isoindoles (adverse effects, pharmacokinetics, pharmacology, therapeutic use)
  • Lurasidone Hydrochloride
  • Schizophrenia (drug therapy)
  • Thiazoles (adverse effects, pharmacokinetics, pharmacology, therapeutic use)

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