Abstract | BACKGROUND:
C-peptide is a surrogate of the pancreatic beta cell mass. However, the clinical significance of C-peptide in a diabetic patient after bariatric surgery has not been studied clearly. METHODS: From February 2005 to January 2009, a total of 205 (124 females and 81 males) consecutive morbidly obese patients with type 2 diabetes mellitus (T2DM) enrolled in a surgically supervised weight loss program with at least 1 year follow-up were examined. Among them, 147 patients (71.7%) received gastric bypass procedures, while the other 58 patients (28.3%) received restrictive-type procedures. RESULTS: The mean C-peptide before the surgery was 5.3 ± 3.5 ng/ml. One hundred nineteen patients (58.0%) had an elevated C-peptide (>4 ng/ml), while 2 patients (1.0%) had a low C-peptide (<1.0 ng/ml). Multivariate analysis confirmed that waist circumference, triglycerides, and HbA1c were the independent predictors for the elevation of C-peptide. It was observed that the mean C-peptide levels decreased to 1.7 ± 0.9 ng/ml 1 year after bariatric surgery with a mean reduction of 64.1%. One year after surgery, 160 patients (78.0%) out of a total of 205 patients had a remission of their T2DM. Patients in the bypass group had a higher diabetes remission rate (91.2%; 134 out of 147) in comparison to patients in the restrictive group (44.8%; 26 out of 58, p < 0.001). The diabetes remission rates for those with preoperative C-peptide <3, 3-6, and > 6 ng/ml were 26 out of 47 (55.3%), 87 out of 108 (82.0%), and 47 out of 52 (90.3%), p < 0.001, respectively. CONCLUSIONS:
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Authors | Wei-Jei Lee, Keong Chong, Kong-Han Ser, Jung-Chien Chen, Yi-Chih Lee, Shu-Chun Chen, Yen-How Su, Min-Han Tsai |
Journal | Obesity surgery
(Obes Surg)
Vol. 22
Issue 2
Pg. 293-8
(Feb 2012)
ISSN: 1708-0428 [Electronic] United States |
PMID | 22139820
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Bariatric Surgery
- Body Mass Index
- C-Peptide
(metabolism)
- Diabetes Mellitus, Type 2
(blood, etiology, surgery)
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Obesity, Morbid
(blood, complications, surgery)
- Predictive Value of Tests
- Remission Induction
- Treatment Outcome
- Weight Loss
- Young Adult
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