The effect of Parodontax® on the MMP-8 concentration in gingivitis patients.

Abstract

The aim of the study was to evaluate the efficacy of Parodontax® (GlaxoSmith-Kline, Bühl, Germany) on the signs gingival inflammation and the enzyme activity of matrix metalloproteinase-8 (aMMP-8) in the gingival crevicular fluid. After approval by the ethics commission, a total of 50 volunteers participated in the study; group 1 (n = 25, age: 43 ± 12 years) with moderate gingivitis (BOP +) and group 2 (n = 25, age: 29 ± 11 years) with clinically healthy gingival conditions (BOP -). After obtaining anamnestic data, the dental examination included assessment of oral hygiene (Quigley & Hein 1962), gingival inflammation (Saxer & Mühlemann 1975), probing pocket depth and clinical attachment level. Gingival crevicular fluid was collected from both groups. A quantitative assessment of aMMP-8 in the gingival crevicular fluid samples was performed (DentoAnalyzer, Dentognostics GmbH, Jena, Germany). Study participants were instructed to use only Parodontax®. After three weeks, all parameters were measured again. The aMMP-8 values of group 1 were significantly reduced after the use of Parodontax® toothpaste and mouthwash (p < 0.001; baseline median 41.25 ± 38.16 ng/ml, final post-treatment median 7.73 ± 7.58 ng/ml aMMP-8 eluate; group 2: baseline median 3.75 ± 3.16 ng/ml, final post-treatment median 3.73 ± 1.54 ng/ml aMMP-8 eluate). Gingival inflammation and plaque accumulation were reduced. It was shown that Parodontax® was effective in reducing the enzymatic activity of inflammation.

• Authors: Vicky Ehlers, Sebastian Helm, Adrian Kasaj, Brita Willershausen
• Journal: Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia (Schweiz Monatsschr Zahnmed) Vol. 121 Issue 11 Pg. 1041-51 ( 2011) ISSN: 0256-2855 [Print] Switzerland
• PMID: 22139737 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Mouthwashes
• Parodontax
• Plant Extracts
• Plant Preparations
• Sodium Bicarbonate
• Matrix Metalloproteinase 8

Topics

• Adult
• Dental Plaque (prevention & control)
• Female
• Gingival Crevicular Fluid (enzymology)
• Gingivitis (drug therapy, enzymology)
• Humans
• Male
• Matrix Metalloproteinase 8 (analysis, metabolism)
• Middle Aged
• Mouthwashes (therapeutic use)
• Phytotherapy
• Plant Extracts (therapeutic use)
• Plant Preparations (therapeutic use)
• Sodium Bicarbonate (therapeutic use)
• Young Adult