Comparison of a dimethicone/antacid (Asilone gel) with an alginate/antacid (Gaviscon liquid) in the management of reflux oesophagitis.

Abstract

Fifty-three patients with symptomatic reflux oesophagitis were entered into a single centre randomized study comparing the effects of a dimethicone/antacid (Asilone Gel) and an alginate/antacid (Gaviscon liquid) on symptoms and endoscopic changes over an 8-week period. Both treatments significantly improved heartburn, acid regurgitation and flatulence. Dimethicone/antacid but not alginate/antacid, produced a significant improvement in oesophagitis, oesophageal ulceration and histological grade of inflammation over the 8-week treatment period so that 14 patients treated with dimethicone/antacid and 10 with alginate/antacid had normal endoscopic oesophageal appearances at the end of the study. The difference in improvement between the two patient groups did not reach significance however, except for dimethicone/antacid improving histological changes (P less than 0.05). These findings suggest that dimethicone/antacid and alginate/antacid are equally effective in treating symptomatic reflux oesophagitis although dimethicone/antacid may have an advantage in improving oesophageal histological appearances.

• Authors: H L Smart, M Atkinson
• Journal: Journal of the Royal Society of Medicine (J R Soc Med) Vol. 83 Issue 9 Pg. 554-6 (Sep 1990) ISSN: 0141-0768 [Print] England
• PMID: 2213800 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Alginates
• Antacids
• Bicarbonates
• Dimethylpolysiloxanes
• Drug Combinations
• aluminium hydroxide, magnesium oxide, simeticone drug combination
• Silicic Acid
• Magnesium Oxide
• Aluminum Hydroxide
• alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination
• Simethicone
• Sodium Bicarbonate

Topics

• Adult
• Alginates (therapeutic use)
• Aluminum Hydroxide (therapeutic use)
• Antacids (therapeutic use)
• Bicarbonates (therapeutic use)
• Dimethylpolysiloxanes
• Double-Blind Method
• Drug Combinations
• Esophagitis, Peptic (drug therapy, pathology)
• Esophagus (pathology)
• Female
• Humans
• Magnesium Oxide (therapeutic use)
• Male
• Silicic Acid (therapeutic use)
• Simethicone (therapeutic use)
• Sodium Bicarbonate