Jeju ground water containing vanadium enhances antioxidant systems in human liver cells.

Abstract

Vanadium compounds have shown promise in the treatment of diabetes and in cancer prevention. The aim of this study is to investigate the effects of Jeju ground water, containing the vanadium compounds S1 (8.0 ± 0.9 μg/l) and S3 (26.0 ± 2.0 μg/l), and of vanadyl sulfate (VOSO(4), 26 μg/l) on antioxidant systems in human Chang liver cells. Cells were incubated for ten passages in media containing deionized distilled water, Jeju ground water (S1, S3), or VOSO(4). S1 and S3 increased the gene and protein expression and the enzymatic activities of antioxidant enzymes, including superoxide dismutase, catalase, glutathione peroxidase, and heme oxygenase. VOSO(4) was likewise found to improve mRNA and protein expression as well as the activities of these enzymes. Taken together, these results suggest that the antioxidant properties of Jeju ground water, containing vanadium compounds, and of vanadyl sulfate were due to stimulatory effects on antioxidant enzyme activities and antioxidant enzyme expression.

• Authors: Areum Daseul Kim, Rui Zhang, Kyoung Ah Kang, Ho Jin You, Kyung Goo Kang, Jin Won Hyun
• Journal: Biological trace element research (Biol Trace Elem Res) Vol. 147 Issue 1-3 Pg. 16-24 (Jun 2012) ISSN: 1559-0720 [Electronic] United States
• PMID: 22134893 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Vanadium Compounds
• vanadyl sulfate
• Catalase
• Glutathione Peroxidase
• Heme Oxygenase (Decyclizing)
• Superoxide Dismutase

Topics

• Antioxidants (metabolism)
• Blotting, Western
• Catalase (genetics, metabolism)
• Cell Line
• Gene Expression Regulation, Enzymologic (drug effects)
• Glutathione Peroxidase (genetics, metabolism)
• Groundwater (chemistry)
• Heme Oxygenase (Decyclizing) (genetics, metabolism)
• Humans
• Liver (cytology, drug effects, metabolism)
• Republic of Korea
• Reverse Transcriptase Polymerase Chain Reaction
• Superoxide Dismutase (genetics, metabolism)
• Vanadium Compounds (pharmacology)