Abstract | PURPOSE: METHODS: Clinical, histological and radiological findings and the management of this case is presented. RESULTS: A 58 year old male with known CVID treated with regular intravenous immunoglobulin infusion, presented with left peri-orbital redness, pain, proptosis and restriction of ocular movements. CT scan showed an ill-defined mass in the left lateral orbit, adjacent to the lacrimal gland. An orbital biopsy revealed a monomorphic lymphocytic infiltrate forming loose lymphoid aggregates in the lacrimal gland tissue. Immunocytochemistry confirmed this to be a reactive inflammatory infiltrate. The patient was successfully treated with a course of oral prednisolone which resulted in improvement of orbital inflammation, ocular movements and proptosis. CONCLUSION: To our knowledge this is the first reported case of non-granulomatous orbital inflammation in association with CVID. This case serves to remind ophthalmologists encountering a patient with CVID that they may have associated orbital inflammatory disease which is responsive to steroid therapy similar to sterile inflammatory masses described in other organs.
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Authors | Purnima Mehta, Swaroop Chickadasarahally, Harpreet Ahluwalia |
Journal | Orbit (Amsterdam, Netherlands)
(Orbit)
Vol. 30
Issue 6
Pg. 313-5
(Dec 2011)
ISSN: 1744-5108 [Electronic] England |
PMID | 22132851
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Glucocorticoids
- Prednisolone
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Topics |
- Biopsy
- Common Variable Immunodeficiency
(complications)
- Diagnosis, Differential
- Glucocorticoids
(therapeutic use)
- Humans
- Inflammation
(diagnosis, drug therapy, etiology)
- Male
- Middle Aged
- Orbital Diseases
(diagnosis, drug therapy, etiology)
- Prednisolone
(therapeutic use)
- Tomography, X-Ray Computed
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