The dentine remineralization activity of a desensitizing bioactive glass-containing toothpaste: an in vitro study.

Abstract

BACKGROUND:

Dentine hypersensitivity occurs easily on exposed dentine. This study aimed to evaluate the effectiveness of a novel bioactive glass-containing toothpaste on dentine permeability and remineralization.

METHODS:

Thirty dentine discs were divided into three groups of 10 specimens each. The groups corresponded to the following brushing treatments: no brush, distilled water, and bioactive glass-containing toothpaste (Novamin). The toothpaste was applied twice a day for 7 days. Dentine permeability was measured after ethylene-diamine-tetraacetic acid (EDTA) etching, initial application, 3-day application, 7-day application and citric acid challenge, respectively. The dentine morphology was investigated using scanning electron microscopy (SEM). Attenuated total reflection Fourier transform infrared (ATR/FTIR) spectroscopy was performed to monitor the mineral variation on demineralized dentine. Qualitative information of elemental variation before and after treatments on completely demineralized dentine was detected by energy dispersive X-ray (EDX) analysis.

RESULTS:

The bioactive glass-containing toothpaste significantly reduced dentine permeability after the 7-day treatment and showed, under SEM, excellent resistance to acid challenge compared to the other groups. ATR/FTIR and EDX revealed increased mineral content after treatment with Novamin.

CONCLUSIONS:

As the innovative bioactive glass-containing toothpaste occlude dentinal tubules and resist acid challenge, it may be useful for the treatment of dentine hypersensitivity and dentine remineralization.

• Authors: Z Wang, T Jiang, S Sauro, D H Pashley, M Toledano, R Osorio, S Liang, W Xing, Y Sa, Y Wang
• Journal: Australian dental journal (Aust Dent J) Vol. 56 Issue 4 Pg. 372-81 (Dec 2011) ISSN: 1834-7819 [Electronic] Australia
• PMID: 22126346 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2011 Australian Dental Association.

Chemical References

• Dentin Desensitizing Agents
• NovaMin
• Phosphates
• Toothpastes
• Calcium

Topics

• Adult
• Calcium (analysis)
• Dentin Desensitizing Agents (therapeutic use)
• Dentin Permeability (drug effects)
• Dentin Sensitivity (drug therapy)
• Glass
• Humans
• Microscopy, Electron, Scanning
• Phosphates (analysis)
• Spectrometry, X-Ray Emission
• Spectroscopy, Fourier Transform Infrared (methods)
• Tooth Remineralization (methods)
• Toothpastes (pharmacology, therapeutic use)