Abstract |
4-Methylpyrazole (4-MP), an inhibitor of alcohol dehydrogenase, may be useful for the treatment of methanol and ethylene glycol intoxications. A placebo-controlled, double blind, multiple dose, sequential, ascending-dose study has been performed to determine the tolerance of 4-MP in healthy volunteers. Oral loading doses of 4-MP were followed by supplemental doses every 12 h through 5 days, producing plasma levels in the therapeutic range. A slight, transient elevation in one or both serum transaminase values was observed in 6 of the 15 subjects treated with 4-MP. This effect was not dose related nor apparently mediated through a hypersensitivity reaction. Serum triglyceride levels were increased in 30% of 4-MP treated subjects, but also in 25% of the placebo subjects. 4-MP treatment did not produce any other significant changes in objective clinical parameters nor in subjective side effects. The results suggest that a mild, transient increase in liver function tests might be observed in some subjects treated with multiple doses of 4-MP. Nevertheless, the slower elimination rate and lesser degree of toxicity of 4-MP would make it preferable to ethanol in therapy of these poisonings.
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Authors | D Jacobsen, C S Sebastian, S K Barron, E W Carriere, K E McMartin |
Journal | The Journal of emergency medicine
(J Emerg Med)
1990 Jul-Aug
Vol. 8
Issue 4
Pg. 455-61
ISSN: 0736-4679 [Print] United States |
PMID | 2212566
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Ethylene Glycols
- Pyrazoles
- Fomepizole
- Alcohol Dehydrogenase
- Methanol
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Topics |
- Adult
- Alcohol Dehydrogenase
(antagonists & inhibitors)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Ethylene Glycols
(metabolism, poisoning)
- Fomepizole
- Humans
- Male
- Methanol
(metabolism, poisoning)
- Poisoning
(drug therapy)
- Pyrazoles
(administration & dosage, adverse effects, therapeutic use)
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