Abstract |
Two rotavirus vaccines have been available since 2006. This study evaluates the effectiveness of these vaccines using a test-negative case-control design in Navarre, Spain. We included children 3-59 months of age who sought medical care for gastroenteritis and for whom stool samples were taken between January 2008 and June 2011. About 9% had received the pentavalent vaccine ( RotaTeq) and another 8% received the monovalent vaccine ( Rotarix). Cases were the 756 children with confirmed rotavirus and controls were the 6036 children who tested negative for rotavirus. Thirty-five percent of cases and 9% of controls had required hospitalization (p<0.0001). The adjusted effectiveness of complete vaccination was 78% (95% CI: 68-85%) in preventing rotavirus gastroenteritis and 83% (95% CI: 65-93%) in preventing hospitalization for rotavirus gastroenteritis. No differences between the two vaccines were detected (p=0.4523). Both vaccines were highly effective in preventing cases and hospital admissions in children due to rotavirus gastroenteritis.
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Authors | Jesús Castilla, Xabier Beristain, Víctor Martínez-Artola, Ana Navascués, Manuel García Cenoz, Nerea Alvarez, Isabel Polo, Ana Mazón, Alberto Gil-Setas, Aurelio Barricarte |
Journal | Vaccine
(Vaccine)
Vol. 30
Issue 3
Pg. 539-43
(Jan 11 2012)
ISSN: 1873-2518 [Electronic] Netherlands |
PMID | 22122860
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011. Published by Elsevier Ltd. |
Chemical References |
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Topics |
- Case-Control Studies
- Child, Preschool
- Feces
(virology)
- Female
- Gastroenteritis
(immunology, prevention & control)
- Hospitalization
(statistics & numerical data)
- Humans
- Infant
- Male
- Rotavirus Infections
(immunology, prevention & control)
- Rotavirus Vaccines
(administration & dosage, immunology)
- Spain
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