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[Comparative study of the efficacy and safety of two anti-emetic protocols in gynecological chemotherapy].

AbstractOBJECTIVES:
To evaluate the efficacy and safety of an update to an anti-emetic protocol in chemotherapy for gynecological tumours.
METHOD:
Prospective observational study performed over 12 months in a general hospital with 400 beds. We evaluated the efficacy of the old anti-emetic protocol, a new protocol was implemented, and its efficacy was determined. We included patients with gynaecological tumours that sought treatment at the Day Hospital. After each chemotherapy cycle, patients filled out a survey that registered the number and severity of episodes of nausea/vomiting and other adverse effects. The efficacy of treatment was measured as complete response (no nausea or vomit) in the acute phase (first 24h after chemotherapy) and late phase (2-5 days after chemotherapy). We also evaluated whether age, the type of protocol, and the emetogenous power of the different treatment schemes could influence patient response.
RESULTS:
We analysed 102 chemotherapy cycles under the old protocol (52 patients) and 293 cycles under the new protocol (98 patients). We observed significant differences in complete response rates in the late phase between old and new protocols (36.27% vs 67.38%, P<.0001). The probability of obtaining a complete response using the new protocol was twice as high as with the old protocol in acute emesis (OR=1.85, 95% CI: 1.05-3.24, P=.03) and four times higher in late emesis (OR=4.27, 95% CI: 2.59-7.02, P<.0001).
CONCLUSIONS:
A greater percentage of complete responses to late emesis was obtained using the new protocol. Age and the low emetogenous power of the treatment schemes were predictive factors for complete response in acute emesis.
AuthorsA de Juan Arroyo, A Urrutia Losada, A López de Torre Querejazu, A Santos Ibáñez, E Ibarra García, I Palacios Zabalza
JournalFarmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria (Farm Hosp) 2012 Jul-Aug Vol. 36 Issue 4 Pg. 220-8 ISSN: 2171-8695 [Electronic] Spain
Vernacular TitleEstudio comparativo de eficacia y seguridad de dos protocolos antieméticos en quimioterapia ginecológica.
PMID22119166 (Publication Type: Comparative Study, English Abstract, Journal Article)
CopyrightCopyright © 2011 SEFH. Published by Elsevier Espana. All rights reserved.
Chemical References
  • Antiemetics
Topics
  • Adult
  • Age Factors
  • Aged
  • Antiemetics (adverse effects, therapeutic use)
  • Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
  • Female
  • Genital Neoplasms, Female (complications, drug therapy)
  • Humans
  • Middle Aged
  • Predictive Value of Tests
  • Vomiting (chemically induced, prevention & control)

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