HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Genetic response to an environmental pathogenic agent: HLA-DQ and onchocerciasis in northwestern Ecuador.

Abstract
The aim of this study is to explore human leukocyte antigen (HLA)-DQ variability in two populations (Cayapas Amerindians and Afro-Ecuadorians) who live near one another along the Cayapa River and who are exposed to the same environmental stresses, such as infection by Onchocerca volvulus. HLA-DQA1 and HLA-DQB1 of 149 unrelated individuals (74 Cayapas and 75 Afro-Ecuadorians) have been analyzed. HLA high-resolution molecular typing was performed by sequence-based typing, sequence-specific oligonucleotides hybridization and sequence-specific primer (SSP) amplification. The comparison between affected (cases) and unaffected people (controls) in both populations shows the key role of several HLA-DQA1 alleles in susceptibility and protection against onchocerciasis. In both populations, there is strong evidence related to the protective role of DQA1*0401 against onchocerciasis. Alleles HLA-DQA1*0102 and *0103 seem to represent risk factors in Afro-Ecuadorians, while HLA-DQA1*0301 is only a suggestive susceptibility allele in Cayapas. These findings represent new positive/negative associations with onchocerciasis in South America, whereas previous findings pertained only to African populations.
AuthorsF De Angelis, A Garzoli, A Battistini, A Iorio, G F De Stefano
JournalTissue antigens (Tissue Antigens) Vol. 79 Issue 2 Pg. 123-9 (Feb 2012) ISSN: 1399-0039 [Electronic] England
PMID22117902 (Publication Type: Journal Article)
Copyright© 2011 John Wiley & Sons A/S.
Chemical References
  • DNA Primers
  • HLA-DQ alpha-Chains
  • HLA-DQ beta-Chains
  • HLA-DQA1 antigen
  • HLA-DQB1 antigen
Topics
  • Adolescent
  • Adult
  • Aged
  • Alleles
  • American Indian or Alaska Native
  • Animals
  • Black People
  • Case-Control Studies
  • Child
  • DNA Primers
  • Disease Susceptibility
  • Ecuador (epidemiology)
  • Female
  • Gene Frequency
  • Gene-Environment Interaction
  • HLA-DQ alpha-Chains (genetics, immunology)
  • HLA-DQ beta-Chains (genetics, immunology)
  • Haplotypes
  • Histocompatibility Testing
  • Humans
  • Male
  • Middle Aged
  • Nucleic Acid Amplification Techniques
  • Onchocerca (immunology)
  • Onchocerciasis (ethnology, genetics, immunology)
  • Polymorphism, Genetic

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: