Chemical and biological properties of rubiginone, a complex of new antibiotics with vincristine-cytotoxicity potentiating activity.

Abstract

A novel complex of isotetracenone (angucyclinone) group antibiotics was discovered from the cultured broth of Streptomyces griseorubiginosus No. Q144-2. The antibiotic consisted of six related factors, designated rubiginones A1, A2, B1, B2, C1 and C2. They significantly potentiated cytotoxicity of vincristine (VCR) against VCR-resistant P388 leukemia and Moser cells.

• Authors: M Oka, H Kamei, Y Hamagishi, K Tomita, T Miyaki, M Konishi, T Oki
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 43 Issue 8 Pg. 967-76 (Aug 1990) ISSN: 0021-8820 [Print] England
• PMID: 2211364 (Publication Type: Journal Article)

Chemical References

• Anthraquinones
• Anti-Bacterial Agents
• rubiginones
• Vincristine

Topics

• Animals
• Anthraquinones (chemistry, isolation & purification, therapeutic use)
• Anti-Bacterial Agents (biosynthesis, chemistry, isolation & purification, therapeutic use)
• Chromatography, Thin Layer
• Colonic Neoplasms (drug therapy)
• Drug Synergism
• Drug Therapy, Combination
• Female
• Fermentation
• Leukemia P388 (drug therapy)
• Magnetic Resonance Spectroscopy
• Mice
• Molecular Structure
• Solubility
• Spectrophotometry
• Streptomyces (classification, metabolism)
• Tumor Cells, Cultured
• Vincristine (therapeutic use)