Abstract | BACKGROUND: METHODS/DESIGN: Auckland's Cancer Cachexia evaluating Resistance Training (ACCeRT) is an open label, prospective, randomised controlled feasibility study with two parallel arms. All patients will be treated with EPA and the COX-2 inhibitor celecoxib on an outpatient basis at the study site. In the experimental group patients will participate in PRT twice a week, followed by the ingestion of essential amino acids high in leucine. A total of 21 patients are planned to be enrolled. Patients will be randomised using 1:2 ratio with 7 patients enrolled into the control arm, and 14 patients into the treatment arm. The primary endpoint is the acceptability of the above multi-targeted approach, determined by an acceptability questionnaire. DISCUSSION: To our knowledge ACCeRT offers for the first time the opportunity to investigate the effect of stimulating the anabolic skeletal muscle pathway with the use of PRT along with EAA alongside the combination of EPA and celecoxib in this population. TRIAL REGISTRATION: Netherlands Trial Register (NTR): ACTRN12611000870954.
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Authors | Elaine S Rogers, Roderick D MacLeod, Joanna Stewart, Stephen P Bird, Justin W L Keogh |
Journal | BMC cancer
(BMC Cancer)
Vol. 11
Pg. 493
(Nov 23 2011)
ISSN: 1471-2407 [Electronic] England |
PMID | 22111896
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amino Acids, Essential
- Cyclooxygenase 2 Inhibitors
- Pyrazoles
- Sulfonamides
- Eicosapentaenoic Acid
- Leucine
- Celecoxib
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Topics |
- Adult
- Amino Acids, Essential
(therapeutic use)
- Cachexia
(therapy)
- Carcinoma, Non-Small-Cell Lung
(complications, therapy)
- Celecoxib
- Combined Modality Therapy
(methods)
- Cyclooxygenase 2 Inhibitors
(therapeutic use)
- Dietary Supplements
- Eicosapentaenoic Acid
(therapeutic use)
- Feasibility Studies
- Female
- Humans
- Leucine
(therapeutic use)
- Lung Neoplasms
(complications, therapy)
- Male
- Middle Aged
- New Zealand
- Patient Satisfaction
- Prospective Studies
- Pyrazoles
(therapeutic use)
- Resistance Training
- Sulfonamides
(therapeutic use)
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