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Pulmonary lymphomatoid granulomatosis in Griscelli syndrome type 2.

Abstract
Griscelli syndrome type 2 (GS2) is a rare autosomal-recessive disorder associated with a RAB27A gene mutation, and clinically manifesting as hypopigmentation, disseminated chronic encephalitis, and severe immunological disorders characterized by an accelerated hematological phase, also referred to as hemophagocytic syndrome (HS), or hemophagocytic lymphohistiocytosis (HLH). The authors report the diagnosis of GS2 in an 11-year-old girl with hypopigmentation, immunodeficiency, hepatosplenomegaly, severe neurological impairments, and fatal multiorgan failure. In this patient a diagnosis of pulmonary lymphomatoid granulomatosis (LG), an Epstein-Barr virus (EBV)-related lymphoproliferative disorder, was established from radiological and histological findings. Although EBV-related malignancies are common in immunocompromised patients, this is the first report of a diagnosis of pulmonary LG in a patient with GS2.
AuthorsAleksandra Szczawinska-Poplonyk, Zdzislawa Kycler, Anna Breborowicz, Maja Klaudel-Dreszler, Malgorzata Pac, Maria Zegadlo-Mylik, Renata Langfort
JournalViral immunology (Viral Immunol) Vol. 24 Issue 6 Pg. 471-3 (Dec 2011) ISSN: 1557-8976 [Electronic] United States
PMID22111599 (Publication Type: Case Reports, Journal Article)
Topics
  • Child
  • Epstein-Barr Virus Infections (complications, virology)
  • Fatal Outcome
  • Female
  • Herpesvirus 4, Human (pathogenicity)
  • Humans
  • Hypopigmentation (genetics)
  • Immunologic Deficiency Syndromes (complications, diagnosis, genetics, virology)
  • Lymphohistiocytosis, Hemophagocytic
  • Lymphomatoid Granulomatosis (complications, genetics)
  • Lymphoproliferative Disorders (genetics)
  • Phenotype
  • Piebaldism (complications, diagnosis, genetics, virology)
  • Primary Immunodeficiency Diseases

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