The development of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO genotypes.

Abstract

BACKGROUND:

Maternal alloantibodies against HPA-1a can cross placenta, opsonize foetal platelets, and induce neonatal alloimmune thrombocytopenia (NAIT). In a study of 100, 448 pregnant women in Norway during 1995-2004, 10.6% of HPA-1a negative women had detectable anti-HPA-1a antibodies.

DESIGN AND METHODS:

A possible correlation between the maternal ABO blood group phenotype, or underlying genotype, and severe thrombocytopenia in the newborn was investigated.

RESULTS:

We observed that immunized women with blood group O had a lower risk of having a child with severe NAIT than women with group A; 20% with blood group O gave birth to children with severe NAIT, compared to 47% among the blood group A mothers (relative risk 0.43; 95% CI 0.25-0.75).

CONCLUSION:

The risk of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO types, and this study indicates that the observation is due to genetic properties on the maternal side.

• Authors: Maria Therese Ahlen, Anne Husebekk, Mette Kjær Killie, Jens Kjeldsen-Kragh, Martin L Olsson, Bjørn Skogen
• Journal: Clinical & developmental immunology (Clin Dev Immunol) Vol. 2012 Pg. 156867 ( 2012) ISSN: 1740-2530 [Electronic] Egypt
• PMID: 22110529 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• ABO Blood-Group System
• Antigens, Human Platelet
• ITGB3 protein, human
• Integrin beta3
• Isoantibodies

Topics

• ABO Blood-Group System (genetics, immunology)
• Antigens, Human Platelet (immunology)
• Female
• Genotype
• Humans
• Infant, Newborn
• Integrin beta3
• Isoantibodies (immunology)
• Phenotype
• Platelet Count
• Pregnancy
• Severity of Illness Index
• Thrombocytopenia, Neonatal Alloimmune (immunology)