Sticky nanoparticles: a platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate.

Abstract

Delivering the goods: Multifunctional, self-assembled, polymeric nanoparticles for the simultaneous delivery of small-molecule drugs and siRNA have been synthesized. The nanoparticles are composed of biodegradable hyaluronic acid, for tumor targeting and cellular delivery, and a high siRNA binding affinity is provided by a Zn(II)-dipicolylamine analogue as an artificial phosphate-binding receptor (see scheme).

• Authors: Gang Liu, Ki Young Choi, Ashwinkumar Bhirde, Magdalena Swierczewska, Juan Yin, Sang Wook Lee, Jae Hyung Park, Jong In Hong, Jin Xie, Gang Niu, Dale O Kiesewetter, Seulki Lee, Xiaoyuan Chen
• Journal: Angewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 51 Issue 2 Pg. 445-9 (Jan 09 2012) ISSN: 1521-3773 [Electronic] Germany
• PMID: 22110006 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Nanoconjugates
• Organometallic Compounds
• Picolines
• RNA, Small Interfering
• zinc(II) dipicolylamine

Topics

• Animals
• Cell Line
• Cell Line, Tumor
• Humans
• Mice
• Nanoconjugates (chemistry)
• Neoplasms (genetics)
• Organometallic Compounds (chemistry)
• Picolines (chemistry)
• RNA Interference
• RNA, Small Interfering (administration & dosage, genetics)