Abstract | PURPOSE: METHODS: In the Osaka University Hospital, conization using the Shimodaira-Taniguchi procedure has been routinely performed for CIN 3. Medical records of patients during the period from 2001 to 2008, whose post-conization diagnosis was CIN 3, were retrospectively analyzed for outcome versus margin status. RESULTS: During the median follow-up period of 565 days (range 34-3,013), CIN disease was again detected in 14 of 243 patients; it was found in 7 patients among 198 margin-negative cases, and in 7 patients among 45 margin-positive cases. There was a significant difference in the reappearance rate demonstrated between the cases with positive and negative margins (p = 0.0018). Among the patients whose first follow-up post-conization cytology was normal, recurrence-free probability was significantly higher in margin-negative cases than in margin-positive ones (hazard ratio, 5.19; 95% CI, 1.175-22.994; p = 0.0041). CONCLUSION: For the first time, we demonstrate that after treatment of CIN 3 lesions by Shimodaira-Taniguchi conization the status of the resection margin was a significant predictor for long-term outcome.
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Authors | Yukari Miyoshi, Takashi Miyatake, Yutaka Ueda, Akiko Morimoto, Takuhei Yokoyama, Shinya Matsuzaki, Toshihiro Kimura, Kiyoshi Yoshino, Masami Fujita, Hiroshi Ohashi, Eiichi Morii, Takayuki Enomoto, Tadashi Kimura |
Journal | Archives of gynecology and obstetrics
(Arch Gynecol Obstet)
Vol. 285
Issue 5
Pg. 1427-32
(May 2012)
ISSN: 1432-0711 [Electronic] Germany |
PMID | 22109382
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Conization
(methods)
- Female
- Humans
- Middle Aged
- Prognosis
- Recurrence
- Uterine Cervical Neoplasms
(diagnosis, surgery)
- Young Adult
- Uterine Cervical Dysplasia
(diagnosis, surgery)
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