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Prediction, based on resection margins, of long-term outcome of cervical intraepithelial neoplasia 3 treated by Shimodaira-Taniguchi conization.

AbstractPURPOSE:
The aim of the present study was to analyze the long-term outcome of cervical intraepithelial neoplasia 3 (CIN 3) after treatment with the Shimodaira-Taniguchi conization procedure, based on the status of the resection margins.
METHODS:
In the Osaka University Hospital, conization using the Shimodaira-Taniguchi procedure has been routinely performed for CIN 3. Medical records of patients during the period from 2001 to 2008, whose post-conization diagnosis was CIN 3, were retrospectively analyzed for outcome versus margin status.
RESULTS:
During the median follow-up period of 565 days (range 34-3,013), CIN disease was again detected in 14 of 243 patients; it was found in 7 patients among 198 margin-negative cases, and in 7 patients among 45 margin-positive cases. There was a significant difference in the reappearance rate demonstrated between the cases with positive and negative margins (p = 0.0018). Among the patients whose first follow-up post-conization cytology was normal, recurrence-free probability was significantly higher in margin-negative cases than in margin-positive ones (hazard ratio, 5.19; 95% CI, 1.175-22.994; p = 0.0041).
CONCLUSION:
For the first time, we demonstrate that after treatment of CIN 3 lesions by Shimodaira-Taniguchi conization the status of the resection margin was a significant predictor for long-term outcome.
AuthorsYukari Miyoshi, Takashi Miyatake, Yutaka Ueda, Akiko Morimoto, Takuhei Yokoyama, Shinya Matsuzaki, Toshihiro Kimura, Kiyoshi Yoshino, Masami Fujita, Hiroshi Ohashi, Eiichi Morii, Takayuki Enomoto, Tadashi Kimura
JournalArchives of gynecology and obstetrics (Arch Gynecol Obstet) Vol. 285 Issue 5 Pg. 1427-32 (May 2012) ISSN: 1432-0711 [Electronic] Germany
PMID22109382 (Publication Type: Journal Article)
Topics
  • Adult
  • Aged
  • Conization (methods)
  • Female
  • Humans
  • Middle Aged
  • Prognosis
  • Recurrence
  • Uterine Cervical Neoplasms (diagnosis, surgery)
  • Young Adult
  • Uterine Cervical Dysplasia (diagnosis, surgery)

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