Central nervous system regulation of food intake and energy expenditure: role of galanin-mediated feeding behavior.

Galanin is a neuropeptide widely expressed in the brain. It is implicated in energy expenditure, feeding, and the regulation of body weight. Numerous studies have revealed that galanin regulates food intake via galanin receptors, 5-HT(1A) receptor and adrenergic α-2 receptor. In this review, we summarize recent findings that reveal the essential role of galanin in increasing food intake as well as body weight and that identify the individual galanin receptor subtypes involved in the brain's modulation of food intake and energy expenditure, to provide a theoretical basis for further studies of different aspects of galanin action.
AuthorsPeng-Hua Fang, Mei Yu, Yin-Ping Ma, Jian Li, Yu-Mei Sui, Ming-Yi Shi
JournalNeuroscience bulletin (Neurosci Bull) Vol. 27 Issue 6 Pg. 407-12 (Dec 2011) ISSN: 1995-8218 [Electronic] China
PMID22108817 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Receptors, Adrenergic, alpha-2
  • Receptors, Galanin
  • Receptor, Serotonin, 5-HT1A
  • Galanin
  • Animals
  • Central Nervous System (drug effects, physiology)
  • Eating (physiology)
  • Energy Metabolism (physiology)
  • Feeding Behavior (drug effects)
  • Galanin (metabolism, pharmacology, physiology)
  • Humans
  • Mice
  • Receptor, Serotonin, 5-HT1A (metabolism)
  • Receptors, Adrenergic, alpha-2 (metabolism)
  • Receptors, Galanin (metabolism)

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