Human recombinant lymphokines and cytokines induce pulmonary eosinophilia in the guinea pig which is inhibited by ketotifen and AH 21-132.

Abstract

Subcutaneous or intraperitoneal injection of recombinant human granulocyte-macrophage colony-stimulating factor, interleukin 3, or mouse tumour necrosis factor alpha, but not recombinant human interferon gamma, platelet-derived growth factor, or transforming growth factor beta caused selective eosinophilia of the pulmonary airways in the guinea pig. Unlike responses to platelet-activating factor, there was no attendant detectable airway hyperreactivity, but in common with responses to platelet-activating factor, eosinophilia of the airways was prevented by pretreatment with ketotifen or AH21-132. Cytokines or lymphokines may contribute to pulmonary eosinophilia in diseases such as asthma.

• Authors: M A Kings, I Chapman, A Kristersson, S Sanjar, J Morley
• Journal: International archives of allergy and applied immunology (Int Arch Allergy Appl Immunol) Vol. 91 Issue 4 Pg. 354-61 ( 1990) ISSN: 0020-5915 [Print] Switzerland
• PMID: 2210871 (Publication Type: Journal Article)

Chemical References

• Cytokines
• Lymphokines
• Naphthyridines
• Recombinant Proteins
• AH 21-132
• Ketotifen

Topics

• Airway Resistance (drug effects)
• Animals
• Bronchoalveolar Lavage Fluid (cytology)
• Cytokines (antagonists & inhibitors, physiology)
• Guinea Pigs
• Ketotifen (pharmacology)
• Leukocyte Count
• Lymphokines (antagonists & inhibitors, physiology)
• Male
• Naphthyridines (pharmacology)
• Pulmonary Eosinophilia (etiology)
• Recombinant Proteins
• Respiratory Function Tests