The dark side of cohesin: the carcinogenic point of view.

Abstract

Genome instability is a hallmark of cancer cells and how it arises is still not completely understood. Correct chromosome segregation is a pre-requisite for preserving genome integrity. Cohesin helps to ensure faithful chromosome segregation during cell cycle, however, much evidence regarding its functions have come to light over the last few years and suggest that cohesin plays multiple roles in the maintenance of genome stability. Here we review our rapidly increasing knowledge on the involvement of cohesin pathway in genome stability and cancer.

• Authors: Linda Mannini, Antonio Musio
• Journal: Mutation research (Mutat Res) 2011 Nov-Dec Vol. 728 Issue 3 Pg. 81-7 ISSN: 0027-5107 [Print] Netherlands
• PMID: 22106471 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Cell Cycle Proteins
• Chromosomal Proteins, Non-Histone
• cohesins

Topics

• Cell Cycle
• Cell Cycle Proteins (physiology)
• Chromosomal Proteins, Non-Histone (physiology)
• Chromosome Segregation
• DNA Damage
• Gene Expression Regulation
• Genomic Instability
• Humans
• Mutation
• Neoplasms (genetics)