Abstract | BACKGROUND:
Macrolides have long been recognised to exert immunomodulary and anti-inflammatory actions. They are able to suppress the " cytokine storm" of inflammation and to confer an additional clinical benefit through their immunomodulatory properties. METHODS: RESULTS:
Macrolide effects are time- and dose-dependent, and the mechanisms underlying these effects remain incompletely understood. Both in vitro and in vivo studies have provided ample evidence of their immunomodulary and anti-inflammatory actions. Importantly, this class of antibiotics is efficacious with respect to controlling exacerbations of underlying respiratory problems, such as cystic fibrosis, asthma, bronchiectasis, panbrochiolitis and cryptogenic organising pneumonia. Macrolides have also been reported to reduce airway hyper-responsiveness and improve pulmonary function. CONCLUSION:
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Authors | P Zarogoulidis, N Papanas, I Kioumis, E Chatzaki, E Maltezos, K Zarogoulidis |
Journal | European journal of clinical pharmacology
(Eur J Clin Pharmacol)
Vol. 68
Issue 5
Pg. 479-503
(May 2012)
ISSN: 1432-1041 [Electronic] Germany |
PMID | 22105373
(Publication Type: Journal Article, Review)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Immunologic Factors
- Macrolides
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Topics |
- Animals
- Anti-Bacterial Agents
(administration & dosage, adverse effects, pharmacology, therapeutic use)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, adverse effects, pharmacology, therapeutic use)
- Cystic Fibrosis
(drug therapy, immunology)
- Humans
- Immunologic Factors
(administration & dosage, adverse effects, pharmacology, therapeutic use)
- Lung Diseases, Obstructive
(drug therapy, immunology)
- Macrolides
(administration & dosage, adverse effects, pharmacology, therapeutic use)
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