Lung malignancies after Hodgkin lymphoma: disease characteristics, detection methods and clinical outcome.

Abstract

BACKGROUND:

Hodgkin lymphoma (HL) survivors have an increased risk of secondary malignancies. We analyzed outcomes in patients with lung cancers following HL treatment.

PATIENTS AND METHODS:

Cases of thoracic malignancies were retrospectively identified from a multi-institutional database of 1976 patients treated for HL from 1969 to 2007. Data regarding risk factors, disease characteristics and outcomes were obtained from medical records.

RESULTS:

Lung malignancies were identified in 55 patients a median of 19.5 years after initial HL therapy. Thirty-one patients (56%) had a >10 pack-year history of tobacco use, 48 (87%) received thoracic irradiation and 26 (47%) received alkylating chemotherapy. Of the 42 patients with known stage at lung cancer diagnosis, 23 (55%) were stage IV and 5 (12%) were stage III. The method of lung cancer detection was known for 35 patients; of these, 12 (34%) were detected incidentally. Median survival time after diagnosis was 10 months for all 55 patients. Median survival time for patients with incidentally detected tumors has not been reached with a median follow-up of 39 months.

CONCLUSIONS:

Lung malignancies diagnosed in patients successfully treated for HL generally have a dismal prognosis. However, a subset of patients diagnosed incidentally may have potentially curable disease.

• Authors: J D Schoenfeld, P M Mauch, P Das, B Silver, K J Marcus, M A Stevenson, A K Ng
• Journal: Annals of oncology : official journal of the European Society for Medical Oncology (Ann Oncol) Vol. 23 Issue 7 Pg. 1813-8 (Jul 2012) ISSN: 1569-8041 [Electronic] England
• PMID: 22104573 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Non-Small-Cell Lung (diagnosis, mortality)
• Female
• Hodgkin Disease (therapy)
• Humans
• Incidental Findings
• Kaplan-Meier Estimate
• Lung Neoplasms (diagnosis, mortality)
• Male
• Middle Aged
• Neoplasms, Second Primary (diagnosis, mortality)
• Retrospective Studies
• Young Adult