Abstract | BACKGROUND: CASE REPORT: CONCLUSION: The evolving acute kidney injury (AKI) provoked a pathologic sequence of reduced renal clearance leading to protracted clearance of carboplatin and subsequent fatal pancytopenia. When AKI occurs in close association with the administration of carboplatin, the institution of rescue hemodialysis is recommended to decrease plasma carboplatin levels and avoid this lethal complication.
|
Authors | Tal Grenader, Linda Shavit |
Journal | Onkologie
(Onkologie)
Vol. 34
Issue 11
Pg. 626-9
( 2011)
ISSN: 1423-0240 [Electronic] Switzerland |
PMID | 22104160
(Publication Type: Case Reports, Journal Article)
|
Copyright | Copyright © 2011 S. Karger AG, Basel. |
Chemical References |
- Antineoplastic Agents
- Carboplatin
|
Topics |
- Acute Kidney Injury
(blood, chemically induced)
- Aged, 80 and over
- Antineoplastic Agents
(adverse effects, blood, therapeutic use)
- Carboplatin
(adverse effects, blood, therapeutic use)
- Carcinoma, Merkel Cell
(blood, complications, drug therapy)
- Fatal Outcome
- Female
- Humans
- Pancytopenia
(blood, chemically induced)
- Skin Neoplasms
(blood, complications, drug therapy)
- Tumor Lysis Syndrome
(blood, etiology)
|