Abstract | CONTEXT: OBJECTIVE: Examine the impact of dietary fish oil on human patients with MetS and NAFLD. MATERIALS AND METHODS: One hundred and forty patients were enrolled in the current study and classified into two groups: patients with both MetS and NAFLD and patients with MetS alone. Sixty-four patients were treated with daily supplementation of 2 g of fish oil for 6 months. Markers of hyperlipidemia and oxidative stress, hydrogen peroxide (H(2)O(2)) and malondialdhyde (MDA), as well as proinflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), were analyzed. RESULTS: Patients without fish oil exhibited significant increases in triglycerides (TGs), low-density lipoprotein ( LDL), H(2)O(2) and MDA that were associated with significantly elevated TNF-α and IL-6 compared to controls. Furthermore, patients with both NAFLD and MetS showed significant increase in H(2)O(2), MDA, TNF-α and IL-6 levels compared with MetS group (p < 0.05). Treatment with fish oil reduced serum level of TG, LDL-cholesterol ( LDL-C), H(2)O(2), MDA, TNF-α and IL-6 levels in patients and did not affect the control levels. DISCUSSION AND CONCLUSION: Patients with NAFLD had bad lipid profile through a mechanism that involved developed redox imbalance, characterized by boosted free-radical activity and lipid peroxidation enhancing the release of proinflammatory cytokines leading to increased MetS risk and liver damage. However, daily treatment of patients with fish oil for 6 months improved lipid profile and blocked the oxidative stress and cytokines release.
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Authors | Mohammed M H Al-Gayyar, Mohamed E E Shams, Enaase A M E Barakat |
Journal | Pharmaceutical biology
(Pharm Biol)
Vol. 50
Issue 3
Pg. 297-303
(Mar 2012)
ISSN: 1744-5116 [Electronic] England |
PMID | 22103753
(Publication Type: Journal Article)
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Chemical References |
- Cytokines
- Fish Oils
- Lipids
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Topics |
- Adult
- Aged
- Case-Control Studies
- Cytokines
(metabolism)
- Egypt
- Fatty Liver
(complications, drug therapy, physiopathology)
- Female
- Fish Oils
(pharmacology)
- Humans
- Inflammation
(drug therapy, physiopathology)
- Lipid Metabolism
(drug effects)
- Lipid Peroxidation
(drug effects)
- Lipids
(blood)
- Male
- Metabolic Syndrome
(complications, drug therapy, physiopathology)
- Middle Aged
- Non-alcoholic Fatty Liver Disease
- Oxidative Stress
(drug effects)
- Prospective Studies
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