HIV-associated anal dysplasia: experience from a multiethnic-HIV clinic in Hawaii.

Abstract

PURPOSE:

To assess the proportion as well as predictors of anal dysplasia in HIV-infected Asian/Pacific Islanders.

METHODS:

This was a retrospective chart review evaluating the proportion of anal dysplasia among a multiethnic population from an ambulatory university-based HIV clinic in Hawaii. Demographic, clinical, and virologic parameters were examined with respect to abnormal anal Pap smear. Variables included: Pap smear results (outcome variable), cytology results, age, self-reported ethnicity, CD4/ nadir CD4 counts, HIV viral load, antiretroviral therapy use, Hepatitis B and C co-infections, history of sexually transmitted diseases, personal history of cancer, tobacco use, alcohol use, intravenous drug abuse, family history of cancer, and history of genital/anal warts.

RESULTS:

There were no significant differences in rates of abnormal Pap smear among the ethnic groups. Abnormal Pap smears were associated with history of genital warts (7% normal vs. 18% abnormal, p=.01) and alcohol consumption (16% vs. 27%, p=.05). Hepatitis B infection and current anti-retroviral therapy (ART) were associated with normal Pap cytology (9.7% vs. 0%, p=.03) and (96.8% vs. 86.5%, p=.05) respectively.

CONCLUSIONS:

No differences in the proportion of abnormal Pap smears were seen among ethnic groups followed within an ambulatory HIV clinic.

• Authors: Ahoora Payam, Bruce Shiramizu, Cecilia Shikuma, Cris Milne, Kevin Terada, Eric Kajioka, Lana Sue Ka'opua, Kevin Cassel, Dominic Chow
• Journal: Journal of health care for the poor and underserved (J Health Care Poor Underserved) Vol. 22 Issue 4 Suppl Pg. 16-22 ( 2011) ISSN: 1548-6869 [Electronic] United States
• PMID: 22102303 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Topics

• Adolescent
• Adult
• Anal Canal (pathology, virology)
• Anus Diseases (epidemiology, pathology, virology)
• Biopsy
• Cross-Sectional Studies
• Ethnicity
• Female
• HIV Infections (complications, epidemiology, pathology)
• Hawaii (epidemiology)
• Humans
• Incidence
• Male
• Mass Screening
• Papillomaviridae (isolation & purification)
• Papillomavirus Infections (complications, epidemiology, pathology, virology)
• Predictive Value of Tests
• Pregnancy
• Prevalence
• Retrospective Studies
• Young Adult