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HIV-associated anal dysplasia: experience from a multiethnic-HIV clinic in Hawaii.

AbstractPURPOSE:
To assess the proportion as well as predictors of anal dysplasia in HIV-infected Asian/Pacific Islanders.
METHODS:
This was a retrospective chart review evaluating the proportion of anal dysplasia among a multiethnic population from an ambulatory university-based HIV clinic in Hawaii. Demographic, clinical, and virologic parameters were examined with respect to abnormal anal Pap smear. Variables included: Pap smear results (outcome variable), cytology results, age, self-reported ethnicity, CD4/ nadir CD4 counts, HIV viral load, antiretroviral therapy use, Hepatitis B and C co-infections, history of sexually transmitted diseases, personal history of cancer, tobacco use, alcohol use, intravenous drug abuse, family history of cancer, and history of genital/anal warts.
RESULTS:
There were no significant differences in rates of abnormal Pap smear among the ethnic groups. Abnormal Pap smears were associated with history of genital warts (7% normal vs. 18% abnormal, p=.01) and alcohol consumption (16% vs. 27%, p=.05). Hepatitis B infection and current anti-retroviral therapy (ART) were associated with normal Pap cytology (9.7% vs. 0%, p=.03) and (96.8% vs. 86.5%, p=.05) respectively.
CONCLUSIONS:
No differences in the proportion of abnormal Pap smears were seen among ethnic groups followed within an ambulatory HIV clinic.
AuthorsAhoora Payam, Bruce Shiramizu, Cecilia Shikuma, Cris Milne, Kevin Terada, Eric Kajioka, Lana Sue Ka'opua, Kevin Cassel, Dominic Chow
JournalJournal of health care for the poor and underserved (J Health Care Poor Underserved) Vol. 22 Issue 4 Suppl Pg. 16-22 ( 2011) ISSN: 1548-6869 [Electronic] United States
PMID22102303 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Topics
  • Adolescent
  • Adult
  • Anal Canal (pathology, virology)
  • Anus Diseases (epidemiology, pathology, virology)
  • Biopsy
  • Cross-Sectional Studies
  • Ethnic Groups
  • Female
  • HIV Infections (complications, epidemiology, pathology)
  • Hawaii (epidemiology)
  • Humans
  • Incidence
  • Male
  • Mass Screening
  • Papillomaviridae (isolation & purification)
  • Papillomavirus Infections (complications, epidemiology, pathology, virology)
  • Predictive Value of Tests
  • Pregnancy
  • Prevalence
  • Retrospective Studies
  • Young Adult

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