Significance of anti-pre-S antibodies in patients with fulminant hepatic failure.

Abstract

Anti-pre-S antibody was tested in 38 sera from patients with fulminant hepatitis (positive for HBsAg and/or IgM anti-HBc) using a specific solid phase enzyme linked immunosorbent assay (ELISA). Anti-pre-S activity was detected in 50 percent sera samples positive for HBsAg but negative for IgM anti-HBc. There were 12.5% sera positive for both HBsAg as well as IgM anti-HBc and 75% sera negative for HBsAg but positive for IgM anti-HBc. The prevalence of HBV-specific DNA-polymerase activity was high in all the three groups whereas anti-HBs positivity was low. Anti-pre-S activity was observed both in the presence as well as in the absence of DNA-polymerase activity. High-anti-pre-S level in fulminant hepatitis B patients was assumed to be implicated in the fast clearance of HBsAg from circulation.

• Authors: M Irshad, B M Gandhi, S K Acharya, Y K Joshi, B N Tandon
• Journal: Gastroenterologia Japonica (Gastroenterol Jpn) Vol. 25 Issue 4 Pg. 499-502 (Aug 1990) ISSN: 0435-1339 [Print] Japan
• PMID: 2210226 (Publication Type: Journal Article)

Chemical References

• Hepatitis B Antibodies
• Hepatitis B Surface Antigens
• Protein Precursors
• Viral Envelope Proteins
• presurface protein 1, hepatitis B surface antigen
• presurface protein 2, hepatitis B surface antigen

Topics

• Hepatic Encephalopathy (immunology, microbiology)
• Hepatitis B (immunology, microbiology)
• Hepatitis B Antibodies (analysis)
• Hepatitis B Surface Antigens (immunology)
• Humans
• Protein Precursors (immunology)
• Viral Envelope Proteins (immunology)