Gender-specific role of the protein tyrosine phosphatase receptor type R gene in major depressive disorder.

Abstract

BACKGROUND:

Major depressive disorder (MDD) is a common, chronic, and recurrent mental disease affecting millions of individuals worldwide. The precise mechanism by which the illness is developed remains unknown, but it has been accepted that a genetic component is very likely to be involved. Studies of the pathogenesis of MDD have implicated a reduced activity of the extracellular regulated kinase (ERK) signaling system. Protein tyrosine phosphatase, receptor type R (PTPRR) is a key negative regulator of the ERK signaling pathway and its expression is regulated by androgen. Therefore, it is worth testing whether the PTPRR gene could confer a risk of MDD.

METHODS:

We genotyped 16 SNPs in the PTPRR locus with the MALDI-TOF-MS-based genotyping protocol in 517 patients with MDD and 455 controls among a Chinese Han population. The UNPHASED program was applied to analyze the genotyping data.

RESULTS:

Of the 16 SNPs selected, rs1513105 was the only one showing allelic association (χ2=9.019, p=0.0027) and genotypic association (χ2=8.813, df=2, p=0.012), of which the rs1513105(C) allele was associated with an increased risk of MDD (OR=1.331, 95% CI 1.104-1.604), but the rs1513105 association resulted mainly from female subjects (χ2=12.35, p=0.00044 for allelic association; χ2=11.26, df=2, p=0.0036 for genotypic association).

LIMITATIONS:

Replication and functional study may be required to draw a firm conclusion.

CONCLUSIONS:

Our results suggest that the PTPRR gene may play a role in conferring risk of MDD in the female subjects.

• Authors: Cuijuan Shi, Kerang Zhang, Qi Xu
• Journal: Journal of affective disorders (J Affect Disord) Vol. 136 Issue 3 Pg. 591-8 (Feb 2012) ISSN: 1573-2517 [Electronic] Netherlands
• PMID: 22100128 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011. Published by Elsevier B.V.

Chemical References

• PTPRR protein, human
• Receptor-Like Protein Tyrosine Phosphatases, Class 7

Topics

• Adult
• China
• Depressive Disorder, Major (genetics)
• Female
• Genotype
• Humans
• Male
• Polymorphism, Single Nucleotide
• Receptor-Like Protein Tyrosine Phosphatases, Class 7 (genetics)
• Young Adult