Abstract | AIMS: Once dismissed as an inert byproduct of nitric oxide (NO) auto-oxidation, nitrite (NO(2)(-)) is now accepted as an endocrine reservoir of NO that elicits biological responses in major organs. While it is known that tissue nitrite is derived from NO oxidation and the diet, little is known about how nitrite is metabolized by tissue, particularly at intermediate oxygen tensions. We investigated the rates and mechanisms of tissue nitrite metabolism over a range of oxygen concentrations. RESULTS: INNOVATION: These data provide insight into the fate of nitrite in tissue, the enzymes involved in nitrite metabolism, and the role of oxygen in regulating these processes. CONCLUSION: We demonstrate that even at low concentrations, oxygen is a potent regulator of the rate and products of tissue nitrite metabolism.
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Authors | Erin Curtis, Lewis L Hsu, Audrey C Noguchi, Lisa Geary, Sruti Shiva |
Journal | Antioxidants & redox signaling
(Antioxid Redox Signal)
Vol. 17
Issue 7
Pg. 951-61
(Oct 01 2012)
ISSN: 1557-7716 [Electronic] United States |
PMID | 22098300
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Nitrites
- Electron Transport Complex IV
- Oxygen
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Topics |
- Animals
- Electron Transport Complex IV
(metabolism)
- Humans
- Mitochondria
(metabolism)
- Nitrites
(metabolism)
- Oxygen
(metabolism)
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