Abstract | BACKGROUND: Several micro-environmental and cell-intrinsic stimuli cause tumor cells to undergo endoplasmic reticulum (ER) stress in vivo. The occurrence of an ER stress response has been associated with tumor progression and angiogenesis. Recently, we found that pharmacological induction of ER stress in B lymphoma cells upregulates the transcription of several pro-inflammatory cytokines. RESULTS: CONCLUSIONS: These results suggest that an ER stress response in prostate cancer cells activates a program of pro-inflammatory cytokine transcription. A possible implication of this finding is that cancer cells may use the ER stress response to modify their microenvironment.
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Authors | Navin R Mahadevan, Antonio Fernandez, Jeffrey J Rodvold, Gonzalo Almanza, Maurizio Zanetti |
Journal | Journal of inflammation research
(J Inflamm Res)
Vol. 3
Pg. 99-103
( 2010)
ISSN: 1178-7031 [Electronic] New Zealand |
PMID | 22096360
(Publication Type: Journal Article)
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