Quantitation of human herpesvirus-6 (HHV-6) DNA in a cord blood transplant recipient with chromosomal integration of HHV-6.

Abstract

Chromosomal integration of the human herpesvirus-6 (HHV-6) genome (CIHHV-6) is an important consideration if HHV-6 DNA is detected during the course of transplantation. A 4-year-old girl with refractory anemia with excess blasts type-2 was diagnosed with CIHHV-6 before a cord blood transplantation. HHV-6 DNA was serially quantitated by polymerase chain reaction assay in the transplant period. The possibility of HHV-6 reactivation in a transplant recipient with CIHHV-6 was suspected in our case.

• Authors: D Kobayashi, K Kogawa, K Imai, T Tanaka, S Hiroi, H Satoh, K Tanaka-Taya, S Nonoyama
• Journal: Transplant infectious disease : an official journal of the Transplantation Society (Transpl Infect Dis) Vol. 13 Issue 6 Pg. 650-3 (Dec 2011) ISSN: 1399-3062 [Electronic] Denmark
• PMID: 22093262 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2011 John Wiley & Sons A/S.

Chemical References

• DNA, Viral

Topics

• Anemia, Refractory, with Excess of Blasts (complications, therapy)
• Child, Preschool
• Cord Blood Stem Cell Transplantation
• DNA, Viral (analysis)
• Female
• Herpesvirus 6, Human (genetics)
• Humans
• Polymerase Chain Reaction
• Postoperative Complications
• Roseolovirus Infections (genetics)
• Viral Load
• Virus Integration (genetics)