Abstract | BACKGROUND: Platelet inhibition is critical in reducing both short- and long-term atherothrombotic risks after acute myocardial infarction (MI), especially among patients managed with percutaneous coronary intervention (PCI). Currently available antiplatelet medications, including adenosine diphosphate ( ADP) receptor inhibitors, have demonstrated variability in efficacy and safety in clinical trials, yet few studies have examined contemporary "real-world" approaches to platelet inhibition and associated outcomes. METHODS: TRANSLATE-ACS is a prospective observational study that will track up to 17,000 MI patients managed with PCI, from the inhospital to outpatient settings for up to 12 months postdischarge to provide a comprehensive picture of current treatment patterns and outcomes in routine clinical practice. TRANSLATE-ACS exemplifies a collaborative study design that efficiently builds upon a well-established PCI registry platform, and yet, through a systematic telephone interview follow-up process, provides important longitudinal clinical and economic follow-up capacity through 15 months after initial MI hospitalization. Furthermore, TRANSLATE-ACS incorporates a hospital-level, clustered, randomized substudy to investigate the impact of point-of-care platelet inhibition testing on subsequent patient management. Finally, TRANSLATE-ACS provides feedback through quarterly reports to participating sites on their care practices benchmarked to peer performance to support and promote longitudinal quality of cardiovascular care delivery. CONCLUSION: TRANSLATE-ACS not only addresses important clinical and scientific questions but also includes pioneering design features that will assist in the evolution of clinical registries.
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Authors | Chee Tang Chin, Tracy Y Wang, Kevin J Anstrom, Baojin Zhu, Jen-Fue Maa, John C Messenger, Kelley A Ryan, Linda Davidson-Ray, Marjorie Zettler, Mark B Effron, Daniel B Mark, Eric D Peterson |
Journal | American heart journal
(Am Heart J)
Vol. 162
Issue 5
Pg. 844-51
(Nov 2011)
ISSN: 1097-6744 [Electronic] United States |
PMID | 22093200
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Mosby, Inc. All rights reserved. |
Chemical References |
- Platelet Aggregation Inhibitors
- Purinergic P2Y Receptor Antagonists
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Topics |
- Acute Coronary Syndrome
(drug therapy)
- Humans
- Longitudinal Studies
- Patient Selection
- Platelet Aggregation Inhibitors
(administration & dosage)
- Purinergic P2Y Receptor Antagonists
(administration & dosage)
- Randomized Controlled Trials as Topic
- Registries
- Research Design
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