Effects of fish oil supplements in NIDDM subjects. Controlled study.

Abstract

The aim of this study was to evaluate the effects of a fish oil preparation (MaxEPA) on hemostatic function and fasting lipid and glucose levels in non-insulin-dependent diabetic (NIDDM) subjects. Eighty NIDDM outpatients aged 55.9 yr (mean SD 11.5 yr) participated in a prospective double-blind placebo-controlled study of MaxEPA capsules (10 g/day) or olive oil (control) treatment over 6 wk. Patients received either MaxEPA or olive oil in addition to preexisting therapy. Metabolic and hemostatic variables were measured before treatment and after 3 and 6 wk. Platelet membrane eicosapentaenoic acid (EPA) content increased in the treatment group (P less than 0.001). MaxEPA supplementation was associated with a significant fall in total triglycerides (P less than 0.001) but did not affect total cholesterol (P = 0.7) compared with control treatment. Fasting plasma glucose increased after 3 wk (P = 0.01) but not after 6 wk (P = 0.17) treatment with MaxEPA. Spontaneous platelet aggregation in whole blood fell in the MaxEPA group (P less than 0.02) after 6 wk, but there were no changes in agonist-induced platelet aggregation, thromboxane generation in platelet-rich plasma, or plasma beta-thromboglobulin and platelet factor IV levels. An increase in clotting factor VII (P = 0.02), without changes in fibrinogen or factor X levels, occurred in the MaxEPA group. Similar reductions in blood pressure were observed in both groups. Dietary supplementation with MaxEPA capsules (10 g/day) in NIDDM subjects is associated with improvement in hypertriglyceridemia but with deleterious effects in factor VII and blood glucose levels. Most indices of platelet function are unaffected by this therapy.

• Authors: T J Hendra, M E Britton, D R Roper, D Wagaine-Twabwe, J Y Jeremy, P Dandona, A P Haines, J S Yudkin
• Journal: Diabetes care (Diabetes Care) Vol. 13 Issue 8 Pg. 821-9 (Aug 1990) ISSN: 0149-5992 [Print] United States
• PMID: 2209315 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Drug Combinations
• Fatty Acids, Omega-3
• Fish Oils
• Lipids
• Maxepa
• Triglycerides
• Docosahexaenoic Acids
• Thromboxane B2
• Cholesterol
• Eicosapentaenoic Acid

Topics

• Blood Glucose (analysis)
• Cardiovascular Diseases (blood, etiology, prevention & control)
• Cholesterol (blood)
• Diabetes Mellitus, Type 2 (blood, complications)
• Diabetic Angiopathies (blood, etiology, prevention & control)
• Diet, Diabetic
• Docosahexaenoic Acids
• Drug Combinations
• Eicosapentaenoic Acid
• Fatty Acids, Omega-3 (administration & dosage, pharmacology)
• Female
• Fish Oils (administration & dosage, pharmacology)
• Food, Fortified
• Hemostasis (drug effects)
• Humans
• Lipids (blood)
• Male
• Thromboxane B2 (blood)
• Triglycerides (blood)