HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Unexplained fetal death has a biological signature of maternal anti-fetal rejection: chronic chorioamnionitis and alloimmune anti-human leucocyte antigen antibodies.

AbstractAIMS:
Chronic chorioamnionitis is a histological manifestation of maternal anti-fetal cellular rejection. As failure of graft survival is the most catastrophic event in organ transplantation, we hypothesized that fetal death could be a consequence of maternal rejection. The aim of this study was to assess whether there is evidence of cellular and antibody-mediated rejection in fetal death.
METHODS AND RESULTS:
Placental histology was reviewed for the presence of chronic chorioamnionitis in unexplained preterm fetal death (n=30) and preterm live birth (n=103). Amniotic fluid CXCL10 concentrations were measured with a specific immunoassay. Chronic chorioamnionitis was more frequent in fetal death than in live birth (60.0% versus 37.9%; P<0.05) and fetal death had a higher median amniotic fluid CXCL10 concentration than live birth (2.0 versus 1.8 ng/ml, P<0.05), after adjusting for gestational age at amniocentesis. Maternal anti-human leucocyte antigen class II panel-reactive seropositivity determined by flow cytometry was higher in fetal death compared to live birth (35.7% versus 10.9%; P<0.05).
CONCLUSIONS:
Chronic chorioamnionitis is a common pathologic feature in unexplained preterm fetal death. This novel finding suggests that cellular and antibody-mediated anti-fetal rejection of the mother is associated with fetal death (graft failure) in human pregnancy.
AuthorsJoonHo Lee, Roberto Romero, Zhong Dong, Yi Xu, Faisal Qureshi, Suzanne Jacques, Wonsuk Yoo, Tinnakorn Chaiworapongsa, Pooja Mittal, Sonia S Hassan, Chong Jai Kim
JournalHistopathology (Histopathology) Vol. 59 Issue 5 Pg. 928-38 (Nov 2011) ISSN: 1365-2559 [Electronic] England
PMID22092404 (Publication Type: Journal Article, Research Support, N.I.H., Intramural)
Copyright© 2011 Blackwell Publishing Limited.
Chemical References
  • Autoantibodies
  • Autoantigens
  • Chemokine CXCL10
  • HLA Antigens
Topics
  • Adolescent
  • Adult
  • Amniotic Fluid (chemistry, immunology)
  • Autoantibodies (blood)
  • Autoantigens (immunology)
  • Chemokine CXCL10 (immunology)
  • Chorioamnionitis (blood, immunology, pathology)
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fetal Death (immunology, pathology)
  • Flow Cytometry
  • HLA Antigens (immunology)
  • Humans
  • Immunohistochemistry
  • Pregnancy
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: