Abstract | OBJECTIVES: DESIGN: Longitudinal cohort study. SETTING: Health, Aging and Body Composition (Health ABC) study. PARTICIPANTS: Three thousand fifty-five participants who were well functioning at baseline (no mobility limitations). MEASUREMENTS: Summated standardized daily doses (low, medium, high) and duration of ACE inhibitor and statin use were computed. Mobility limitation (two consecutive self-reports of having any difficulty walking one-quarter of a mile or climbing 10 steps without resting) was assessed every 6 months after baseline. Multivariable Cox proportional hazards analyses were conducted, adjusting for demographics, health status, and health behaviors. RESULTS: At baseline, 15.2% used ACE inhibitors and 12.9% used statins; use of both was greater than 25% by Year 6. Over 6.5 years of follow-up, 49.8% had developed mobility limitation. In separate multivariable models, neither ACE inhibitor (multivariate hazard ratio (HR) = 0.95, 95% confidence interval (CI) = 0.82-1.09) nor statin use (multivariate HR = 1.02, 95% CI = 0.87-1.17) was associated with lower risk of mobility limitation. Similar findings were seen in analyses examining dose-response and duration-response relationships and a sensitivity analysis restricted to those with hypertension. CONCLUSION:
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Authors | Shelly L Gray, Robert M Boudreau, Anne B Newman, Stephanie A Studenski, Ronald I Shorr, Douglas C Bauer, Eleanor M Simonsick, Joseph T Hanlon, Health, Aging and Body Composition Study |
Journal | Journal of the American Geriatrics Society
(J Am Geriatr Soc)
Vol. 59
Issue 12
Pg. 2226-32
(Dec 2011)
ISSN: 1532-5415 [Electronic] United States |
PMID | 22092102
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Copyright | © 2011, Copyright the Authors Journal compilation © 2011, The American Geriatrics Society. |
Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Topics |
- Aged
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Dose-Response Relationship, Drug
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Longitudinal Studies
- Male
- Mobility Limitation
- Residence Characteristics
- Time Factors
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