Abstract | BACKGROUND: METHODS: A total of 110 adults (18 to 83 y) of American Society of Anesthesiologists physical status I-III undergoing elective lumbar microdiscectomy with intubated total intravenous anesthesia were randomly divided into 2 groups of 55 each. The patients assigned to the fentanyl group received a dose of 1 μg/kg of fentanyl, whereas those assigned to the tramadol group received 1 mg/kg of tramadol, at the beginning of skin closure. We recorded the incidence of cough, quality of extubation at fixed times, maximal heart rates, maximal blood pressure during emergence, postoperative pain scores, and consumption of fentanyl. In addition, postoperative sore throat (POST), hoarseness, postoperative nausea and vomiting, and other anesthetic and surgical-related complications were recorded. RESULTS: CONCLUSIONS: A dose of 1 mg/kg of tramadol administered intravenously 30 minutes before the expected extubation, compared with 1 μg/kg of fentanyl, decreased cough incidence, improved emergence quality, and provided stable hemodynamics. However, there was no significant difference between tramadol and fentanyl in pain scores and fentanyl consumption postoperatively.
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Authors | Bo-Feng Lin, Da-Tong Ju, Chen-Hwan Cherng, Nan-Kai Hung, Chun-Chang Yeh, Shun-Ming Chan, Ching-Tang Wu |
Journal | Journal of neurosurgical anesthesiology
(J Neurosurg Anesthesiol)
Vol. 24
Issue 2
Pg. 127-32
(Apr 2012)
ISSN: 1537-1921 [Electronic] United States |
PMID | 22089326
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics, Opioid
- Narcotics
- Tramadol
- Fentanyl
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Analgesics, Opioid
(pharmacology, therapeutic use)
- Anesthesia Recovery Period
- Blood Pressure
(drug effects)
- Cough
(prevention & control)
- Diskectomy
- Female
- Fentanyl
(pharmacology, therapeutic use)
- Heart Rate
(drug effects)
- Humans
- Intraoperative Period
- Male
- Middle Aged
- Narcotics
(pharmacology, therapeutic use)
- Pain, Postoperative
(prevention & control)
- Postoperative Complications
(prevention & control)
- Severity of Illness Index
- Tramadol
(pharmacology, therapeutic use)
- Young Adult
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