HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Comparison between intraoperative fentanyl and tramadol to improve quality of emergence.

AbstractBACKGROUND:
Cough causes poor quality of emergence from anesthesia and risks of several complications. We compared fentanyl and an antitussive action of tramadol on the quality of emergence and postoperative outcome.
METHODS:
A total of 110 adults (18 to 83 y) of American Society of Anesthesiologists physical status I-III undergoing elective lumbar microdiscectomy with intubated total intravenous anesthesia were randomly divided into 2 groups of 55 each. The patients assigned to the fentanyl group received a dose of 1 μg/kg of fentanyl, whereas those assigned to the tramadol group received 1 mg/kg of tramadol, at the beginning of skin closure. We recorded the incidence of cough, quality of extubation at fixed times, maximal heart rates, maximal blood pressure during emergence, postoperative pain scores, and consumption of fentanyl. In addition, postoperative sore throat (POST), hoarseness, postoperative nausea and vomiting, and other anesthetic and surgical-related complications were recorded.
RESULTS:
Tramadol reduced cough incidence, improved extubation quality, and provided more stable hemodynamics during emergence. There was no significant difference in postoperative pain, fentanyl consumption, incidence and severity of POST, hoarseness, and postoperative nausea and vomiting between groups. Moreover, we found that the incidence of POST did not correlate with cough incidence.
CONCLUSIONS:
A dose of 1 mg/kg of tramadol administered intravenously 30 minutes before the expected extubation, compared with 1 μg/kg of fentanyl, decreased cough incidence, improved emergence quality, and provided stable hemodynamics. However, there was no significant difference between tramadol and fentanyl in pain scores and fentanyl consumption postoperatively.
AuthorsBo-Feng Lin, Da-Tong Ju, Chen-Hwan Cherng, Nan-Kai Hung, Chun-Chang Yeh, Shun-Ming Chan, Ching-Tang Wu
JournalJournal of neurosurgical anesthesiology (J Neurosurg Anesthesiol) Vol. 24 Issue 2 Pg. 127-32 (Apr 2012) ISSN: 1537-1921 [Electronic] United States
PMID22089326 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Analgesics, Opioid
  • Narcotics
  • Tramadol
  • Fentanyl
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Analgesics, Opioid (pharmacology, therapeutic use)
  • Anesthesia Recovery Period
  • Blood Pressure (drug effects)
  • Cough (prevention & control)
  • Diskectomy
  • Female
  • Fentanyl (pharmacology, therapeutic use)
  • Heart Rate (drug effects)
  • Humans
  • Intraoperative Period
  • Male
  • Middle Aged
  • Narcotics (pharmacology, therapeutic use)
  • Pain, Postoperative (prevention & control)
  • Postoperative Complications (prevention & control)
  • Severity of Illness Index
  • Tramadol (pharmacology, therapeutic use)
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: