Abstract | BACKGROUND: METHODS AND RESULTS:
Ventricular fibrillation was induced and untreated for 8 minutes in 24 male Sprague-Dawley rats. Defibrillation was attempted after 8 minutes of cardiopulmonary resuscitation. Seven minutes after resuscitation, animals were randomized into 4 groups (n=6 each): normothermic, hypothermic-2 hours, hypothermic-5 hours, and hypothermic-8 hours. Animals in the hypothermic groups received rapid cooling, which was started 7 minutes after restoration of spontaneous circulation and maintained at 33±0.5°C for 2, 5, or 8 hours. Normothermic animals were maintained at 37±0.2°C. All animals were anesthetized and ventilated for 8 hours after resuscitation. Blood temperature was significantly decreased in the hypothermic groups. Postresuscitation myocardial function, neurological deficit scores, and 72-hour survival were significantly better in animals treated with hypothermia regardless of the duration of cooling. However, significantly better postresuscitation tissue microcirculation, myocardial ejection fraction, and neurological deficit scores were observed in the hypothermic-2 hours animals. CONCLUSIONS:
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Authors | Sen Ye, Yinlun Weng, Shijie Sun, Wei Chen, Xiaobo Wu, Zilong Li, Max Harry Weil, Wanchun Tang |
Journal | Circulation
(Circulation)
Vol. 125
Issue 1
Pg. 123-9
(Jan 03 2012)
ISSN: 1524-4539 [Electronic] United States |
PMID | 22086880
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Animals
- Body Temperature
(physiology)
- Cardiopulmonary Resuscitation
(methods)
- Heart Arrest
(physiopathology, therapy)
- Hypothermia, Induced
(methods)
- Male
- Microcirculation
(physiology)
- Rats
- Rats, Sprague-Dawley
- Time Factors
- Treatment Outcome
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