Occupational exposure to benzene and chromosomal structural aberrations in the sperm of Chinese men.
Abstract | BACKGROUND:
Benzene is an industrial chemical that causes blood disorders, including acute myeloid leukemia. We previously reported that occupational exposures near the U.S. Occupational Safety and Health Administration permissible exposure limit (8 hr) of 1 ppm was associated with sperm aneuploidy. OBJECTIVE: We investigated whether occupational exposures near 1 ppm increase the incidence of sperm carrying structural chromosomal aberrations. METHODS: We applied a sperm fluorescence in situ hybridization assay to measure frequencies of sperm carrying partial chromosomal duplications or deletions of 1cen or 1p36.3 or breaks within 1cen-1q12 among 30 benzene-exposed and 11 unexposed workers in Tianjin, China, as part of the China Benzene and Sperm Study (C-BASS). Exposed workers were categorized into low-, moderate-, and high-exposure groups based on urinary benzene (medians: 2.9, 11.0, and 110.6 µg/L, respectively). Median air benzene concentrations in the three exposure groups were 1.2, 3.7, and 8.4 ppm, respectively. RESULTS: Adjusted incidence rate ratios (IRRs) and 95% confidence intervals (CIs) for all structural aberrations combined were 1.42 (95% CI: 1.10, 1.83), 1.44 (95% CI: 1.12, 1.85), and 1.75 (95% CI: 1.36, 2.24) and for deletion of 1p36.3 alone were 4.31 (95% CI: 1.18, 15.78), 6.02 (95% CI: 1.69, 21.39), and 7.88 (95% CI: 2.21, 28.05) for men with low, moderate, and high exposure, respectively, compared with unexposed men. Chromosome breaks were significantly increased in the high-exposure group [ IRR 1.49 (95% CI: 1.10, 2.02)]. CONCLUSIONS:
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Authors | Francesco Marchetti, Brenda Eskenazi, Rosana H Weldon, Guilan Li, Luoping Zhang, Stephen M Rappaport, Thomas E Schmid, Caihong Xing, Elaine Kurtovich, Andrew J Wyrobek |
Journal | Environmental health perspectives
(Environ Health Perspect)
Vol. 120
Issue 2
Pg. 229-34
(Feb 2012)
ISSN: 1552-9924 [Electronic] United States |
PMID | 22086566
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Environmental Pollutants
- muconic acid
- Benzene
- Sorbic Acid
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Topics |
- Adult
- Benzene
(analysis, standards, toxicity)
- China
- Chromosome Aberrations
(chemically induced)
- Dose-Response Relationship, Drug
- Environmental Pollutants
(standards, toxicity, urine)
- Humans
- In Situ Hybridization, Fluorescence
- Male
- Middle Aged
- Occupational Exposure
- Sorbic Acid
(analogs & derivatives, analysis)
- Spermatozoa
(drug effects)
- Young Adult
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